This HTML5 document contains 58 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n20http://localhost/temp/predkladatel/
n17http://linked.opendata.cz/resource/domain/vavai/projekt/
n8http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n18http://linked.opendata.cz/ontology/domain/vavai/
n14http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n15http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
n7http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216224%3A14310%2F04%3A00064402%21RIV13-MSM-14310___/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n12http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n19http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n9http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n10http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n5http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F04%3A00064402%21RIV13-MSM-14310___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
This in vivo study employs p27-deficient mice to investigate the significance of p27 for the metabolism of D-type cyclins in differentiated cells. The absence of p27 results in decreased levels of cyclins D2 and/or D3 in some organs. As demonstrated on Leydig cells of testis, such dependency is only restricted to certain cell types including terminally differentiated ones, and the absence of p27 in these cells can interfere with their differentiation. The decrease of cyclin D caused by the absence of p27 equals the amount of cyclin D physically associated with p27 in non-mutant animals. The data indicate that it is the proportion of p27-associated cyclin D that determines the response to p27 deficiency. Cells in which the level of D-type cyclin is dependent on p27 do not up-regulate the activity of their CDK2 and CDK4 upon loss of p27, and these cells have a negligible amount of p27 bound to CDK2 and/or cyclin A/E under normal conditions. This in vivo study employs p27-deficient mice to investigate the significance of p27 for the metabolism of D-type cyclins in differentiated cells. The absence of p27 results in decreased levels of cyclins D2 and/or D3 in some organs. As demonstrated on Leydig cells of testis, such dependency is only restricted to certain cell types including terminally differentiated ones, and the absence of p27 in these cells can interfere with their differentiation. The decrease of cyclin D caused by the absence of p27 equals the amount of cyclin D physically associated with p27 in non-mutant animals. The data indicate that it is the proportion of p27-associated cyclin D that determines the response to p27 deficiency. Cells in which the level of D-type cyclin is dependent on p27 do not up-regulate the activity of their CDK2 and CDK4 upon loss of p27, and these cells have a negligible amount of p27 bound to CDK2 and/or cyclin A/E under normal conditions.
dcterms:title
The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo
skos:prefLabel
The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo
skos:notation
RIV/00216224:14310/04:00064402!RIV13-MSM-14310___
n3:aktivita
n4:P n4:Z n4:I
n3:aktivity
I, P(GA204/01/0905), P(LN00A065), Z(AV0Z5039906), Z(MSM 432100001)
n3:cisloPeriodika
2-3
n3:dodaniDat
n5:2013
n3:domaciTvurceVysledku
n8:5512646 n8:6215750 n8:8855803 n8:2911574
n3:druhVysledku
n10:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
584993
n3:idVysledku
RIV/00216224:14310/04:00064402
n3:jazykVysledku
n9:eng
n3:klicovaSlova
D-type cyclin; p27; differentiation; p27-deficient mouse; Leydig cell; thymus; lung
n3:klicoveSlovo
n12:p27-deficient%20mouse n12:differentiation n12:Leydig%20cell n12:D-type%20cyclin n12:lung n12:p27 n12:thymus
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[B84F1623BF9A]
n3:nazevZdroje
Biochimica et biophysica acta : Molecular Cell Research
n3:obor
n16:ED
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
8
n3:projekt
n17:LN00A065 n17:GA204%2F01%2F0905
n3:rokUplatneniVysledku
n5:2004
n3:svazekPeriodika
1691
n3:tvurceVysledku
Bryja, Vítězslav Faldíková, Ludmila Dvořák, Petr Pacherník, Jiří Krejčí, Pavel Nevriva, I Pogue, R. Hampl, Aleš
n3:wos
000221211800004
n3:zamer
n14:MSM%20432100001 n14:AV0Z5039906
s:issn
0167-4889
s:numberOfPages
12
n15:doi
10.1016/j.bbamer.2004.01.001
n20:organizacniJednotka
14310