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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F04%3A00035987%21RIV10-MSM-14310___
rdf:type
skos:Concept n21:Vysledek
dcterms:description
The title compds. pyrazolo[1,5-a]pyrimidines [I R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I is claimed. The title compds. pyrazolo[1,5-a]pyrimidines [I R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I is claimed.
dcterms:title
Pyrazolopyrimidines as cyclin-dependent kinase inhibitors Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
skos:prefLabel
Pyrazolopyrimidines as cyclin-dependent kinase inhibitors Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
skos:notation
RIV/00216224:14310/04:00035987!RIV10-MSM-14310___
n3:datumRegistracePatentuVzoru
2004-02-11+01:00
n3:aktivita
n10:N
n3:aktivity
N
n3:cisloPatentuVzoru
US 2004/209878 A1
n3:datumUdeleniPatentuVzoru
2004-10-21+02:00
n3:dodaniDat
n11:2010
n3:domaciTvurceVysledku
n18:1390333
n3:druhVysledku
n20:P
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
583275
n3:idVysledku
RIV/00216224:14310/04:00035987
n3:jazykVysledku
n15:eng
n3:klicovaSlova
cyclin dependent kinase; inhibitor; pyrazolopyrimidine
n3:klicoveSlovo
n14:inhibitor n14:cyclin%20dependent%20kinase n14:pyrazolopyrimidine
n3:kontrolniKodProRIV
[727FD9C0A3D6]
n3:licencniPoplatek
n19:A
n3:mistoVydaniPatentuVzoru
USA
n3:nazevVydavatelePatentuVzoru
United States Patent and Trademark Office
n3:obor
n4:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
19
n3:rokUplatneniVysledku
n11:2004
n3:statVydaniPatentuVzoru
n8:US
n3:tvurceVysledku
Fischmann, Thierry Park, Haengsoon Tran, Vinh Paruch, Kamil Guzi, Timothy Paradkar, Vidyadhar Girijavallabhan, Viyyoor Madison, Vincent Dwyer, Michael Keertikar, Kartik James, Ray Doll, Ronald Hobbs, Douglas Alvarez, Carmen Zhen, Min Chan, Tin-Yau Mallams, Alan Dillard, Lawrence Rivera, Jocelyn
n3:uzemniOchranaPatentu
n9:B
n3:vlastnik
n6:vlastnikVysledku
n3:vyuzitiJinymSubjektem
n16:A
n3:vyuzitiPatentuVzoru
n13:A
n3:vlastnikPatentuVzoru
Schering-Plough
n17:organizacniJednotka
14310