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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F04%3A00021349%21RIV08-MSM-14310___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Ribosomal RNA K-turn motifs are asymmetric internal loops characterized by a sharp bend in the phosphodiester backbone resulting in "V" shaped structures, recurrently observed in ribosomes and showing high degree of sequence conservation. We have carried out extended explicit solvent molecular dynamics simulations of selected K-turns, in order to investigate their intrinsic structural and dynamical properties. The simulations reveal an unprecedented dynamical flexibility of the K-turns around their x-ray geometries. The K-turns sample, on the nanosecond timescale, different conformational substates. The overall behaviour of the simulations suggests that the sampled geometries are essentially isoenergetic and separated by minimal energy barriers. The nanosecond dynamics of isolated K-turns can be qualitatively considered as motion of two rigid helix stems controlled by a very flexible internal loop which then leads to substantial hinge-like motions between the two stems. This internal dynamic Ribosomal RNA K-turn motifs are asymmetric internal loops characterized by a sharp bend in the phosphodiester backbone resulting in "V" shaped structures, recurrently observed in ribosomes and showing high degree of sequence conservation. We have carried out extended explicit solvent molecular dynamics simulations of selected K-turns, in order to investigate their intrinsic structural and dynamical properties. The simulations reveal an unprecedented dynamical flexibility of the K-turns around their x-ray geometries. The K-turns sample, on the nanosecond timescale, different conformational substates. The overall behaviour of the simulations suggests that the sampled geometries are essentially isoenergetic and separated by minimal energy barriers. The nanosecond dynamics of isolated K-turns can be qualitatively considered as motion of two rigid helix stems controlled by a very flexible internal loop which then leads to substantial hinge-like motions between the two stems. This internal dynamic Ribosomal RNA K-turn motifs are asymmetric internal loops characterized by a sharp bend in the phosphodiester backbone resulting in "V" shaped structures, recurrently observed in ribosomes and showing high degree of sequence conservation. We have carried out extended explicit solvent molecular dynamics simulations of selected K-turns, in order to investigate their intrinsic structural and dynamical properties. The simulations reveal an unprecedented dynamical flexibility of the K-turns around their x-ray geometries. The K-turns sample, on the nanosecond timescale, different conformational substates. The overall behaviour of the simulations suggests that the sampled geometries are essentially isoenergetic and separated by minimal energy barriers. The nanosecond dynamics of isolated K-turns can be qualitatively considered as motion of two rigid helix stems controlled by a very flexible internal loop which then leads to substantial hinge-like motions between the two stems. This internal dynamic
dcterms:title
Ribosomal RNA Kink-turn motif - a flexible molecular hinge Ribosomal RNA Kink-turn motif - a flexible molecular hinge Ribozomalny Kink-turn motiv - flexibilny molekularny klb
skos:prefLabel
Ribozomalny Kink-turn motiv - flexibilny molekularny klb Ribosomal RNA Kink-turn motif - a flexible molecular hinge Ribosomal RNA Kink-turn motif - a flexible molecular hinge
skos:notation
RIV/00216224:14310/04:00021349!RIV08-MSM-14310___
n3:strany
87-87
n3:aktivita
n11:P
n3:aktivity
P(LN00A016)
n3:dodaniDat
n16:2008
n3:domaciTvurceVysledku
n7:4347374 n7:3223779 n7:9031510 n7:7167830 n7:4585623
n3:druhVysledku
n4:D
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
584679
n3:idVysledku
RIV/00216224:14310/04:00021349
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Kink turn; RNA flexibility
n3:klicoveSlovo
n9:RNA%20flexibility n9:Kink%20turn
n3:kontrolniKodProRIV
[F4E9567BFB44]
n3:mistoKonaniAkce
Jackson, MS, USA
n3:mistoVydani
Jackson, MS, USA
n3:nazevZdroje
Conference on Current Trends in Computational Chemistry
n3:obor
n13:CF
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:projekt
n19:LN00A016
n3:rokUplatneniVysledku
n16:2004
n3:tvurceVysledku
Rázga, Filip Špačková, Naděžda Leontis, Neocles B. Koča, Jaroslav Šponer, Jiří Réblová, Kamila
n3:typAkce
n20:WRD
n3:zahajeniAkce
2004-01-01+01:00
s:numberOfPages
1
n12:hasPublisher
Jackson, Miss, USA
n5:organizacniJednotka
14310