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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F04%3A00009963%21RIV08-MSM-14310___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
A series of different racemic aryloxyaminopropan-2-ol derivatives 1a-d-3a-d with potential -adrenergic blocking effects related to propanolol 4 and atenolol 5 was resolved by HPLC using Chiralcel OD-H and Chiralpak AD as chiral stationary phases. Mobile phases consisted of a hexane/alcohol (propan-2-ol or ethanol) mixture doped with a modifier (DEA or TFA). The retention behavior of the compounds depended on the position of the carbamate attached to the aryloxy moiety and on the length of the alkyl residue in the carbamate. Enantiomers of the title compounds were baseline separated with the separation factors and resolutions Rs varying in the range of 1.34-4.55 and 1.50-10.65, respectively. The chromatographic systems developed can be used for the determination of the enantiomeric purity of the title compounds. Molecular modelling using empirical molecular mechanics and ab initio quantum chemistry methods provided low-energy structures in which sites of potential interactions responsible for retention Chromatografie a modelování nových aryloxyaminopropan-2-olů A series of different racemic aryloxyaminopropan-2-ol derivatives 1a-d-3a-d with potential -adrenergic blocking effects related to propanolol 4 and atenolol 5 was resolved by HPLC using Chiralcel OD-H and Chiralpak AD as chiral stationary phases. Mobile phases consisted of a hexane/alcohol (propan-2-ol or ethanol) mixture doped with a modifier (DEA or TFA). The retention behavior of the compounds depended on the position of the carbamate attached to the aryloxy moiety and on the length of the alkyl residue in the carbamate. Enantiomers of the title compounds were baseline separated with the separation factors and resolutions Rs varying in the range of 1.34-4.55 and 1.50-10.65, respectively. The chromatographic systems developed can be used for the determination of the enantiomeric purity of the title compounds. Molecular modelling using empirical molecular mechanics and ab initio quantum chemistry methods provided low-energy structures in which sites of potential interactions responsible for retention
dcterms:title
Enantioselective chromatography and molecular modeling of novel aryloxyaminopropan-2-ols with the alkyl carbamate function. Chromatografie a modelování nových aryloxyaminopropan-2-olů Enantioselective chromatography and molecular modeling of novel aryloxyaminopropan-2-ols with the alkyl carbamate function.
skos:prefLabel
Enantioselective chromatography and molecular modeling of novel aryloxyaminopropan-2-ols with the alkyl carbamate function. Enantioselective chromatography and molecular modeling of novel aryloxyaminopropan-2-ols with the alkyl carbamate function. Chromatografie a modelování nových aryloxyaminopropan-2-olů
skos:notation
RIV/00216224:14310/04:00009963!RIV08-MSM-14310___
n3:strany
139-146
n3:aktivita
n15:P n15:Z
n3:aktivity
P(LN00A016), Z(MSM 163700003)
n3:cisloPeriodika
3
n3:dodaniDat
n6:2008
n3:domaciTvurceVysledku
n4:4347374 n4:9309616 n4:5305179
n3:druhVysledku
n13:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
562793
n3:idVysledku
RIV/00216224:14310/04:00009963
n3:jazykVysledku
n7:eng
n3:klicovaSlova
aryloxyaminopropanols; enantioselective HPLC; Chiralcel OD-H; Chiralpak AD; chiral recognition; low-energy conformers; molecular modeling
n3:klicoveSlovo
n11:chiral%20recognition n11:enantioselective%20HPLC n11:aryloxyaminopropanols n11:Chiralcel%20OD-H n11:Chiralpak%20AD n11:low-energy%20conformers n11:molecular%20modeling
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[BAAD70064024]
n3:nazevZdroje
Chirality
n3:obor
n16:CC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n12:LN00A016
n3:rokUplatneniVysledku
n6:2004
n3:svazekPeriodika
16
n3:tvurceVysledku
Navrátilová, Hana Kříž, Zdeněk Opatřilová, Radka Koča, Jaroslav
n3:zamer
n18:MSM%20163700003
s:numberOfPages
8
n5:organizacniJednotka
14310