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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F04%3A00009958%21RIV%2F2005%2FMSM%2F143105%2FN
rdf:type
skos:Concept n20:Vysledek
dcterms:description
Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. These motifs, asymmetric internal loops, are called Kink-turns (K-turns), and are characterized by a sharp, ca. 120 deg. bend in both phosphodiester backbones producing a V-shaped structure with an acute angle of ca. 60 deg. between the flanking RNA helices. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs, including K-turn 38 (Kt-38) occurred in the A-site finger, Kt-42 occurred in the Factor-binding domain and Kt-58 occurred in the Domain III from the 23S ribosomal RNA of H. marismortui. The presence of K-turns at these key functional sites of the 50S subunit of the ribosome suggests that they confer flexibility to RNA Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. These motifs, asymmetric internal loops, are called Kink-turns (K-turns), and are characterized by a sharp, ca. 120 deg. bend in both phosphodiester backbones producing a V-shaped structure with an acute angle of ca. 60 deg. between the flanking RNA helices. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs, including K-turn 38 (Kt-38) occurred in the A-site finger, Kt-42 occurred in the Factor-binding domain and Kt-58 occurred in the Domain III from the 23S ribosomal RNA of H. marismortui. The presence of K-turns at these key functional sites of the 50S subunit of the ribosome suggests that they confer flexibility to RNA Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. These motifs, asymmetric internal loops, are called Kink-turns (K-turns), and are characterized by a sharp, ca. 120 deg. bend in both phosphodiester backbones producing a V-shaped structure with an acute angle of ca. 60 deg. between the flanking RNA helices. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn motifs, including K-turn 38 (Kt-38) occurred in the A-site finger, Kt-42 occurred in the Factor-binding domain and Kt-58 occurred in the Domain III from the 23S ribosomal RNA of H. marismortui. The presence of K-turns at these key functional sites of the 50S subunit of the ribosome suggests that they confer flexibility to RNA
dcterms:title
Dynamics of Flexible RNA Hinges Relevant to Ribosome Function: non-Watson-Crick basepairs, modular building and specific hydration of RNA Kink-turns Dynamics of Flexible RNA Hinges Relevant to Ribosome Function: non-Watson-Crick basepairs, modular building and specific hydration of RNA Kink-turns Dynamika flexibilnych RNA pantov dolezitych pre funkciu ribozomu: ne-Watson-Crick-ovske pary bazi, modularna vystavba a specificka hydratacia RNA Kink-turn motivov
skos:prefLabel
Dynamics of Flexible RNA Hinges Relevant to Ribosome Function: non-Watson-Crick basepairs, modular building and specific hydration of RNA Kink-turns Dynamics of Flexible RNA Hinges Relevant to Ribosome Function: non-Watson-Crick basepairs, modular building and specific hydration of RNA Kink-turns Dynamika flexibilnych RNA pantov dolezitych pre funkciu ribozomu: ne-Watson-Crick-ovske pary bazi, modularna vystavba a specificka hydratacia RNA Kink-turn motivov
skos:notation
RIV/00216224:14310/04:00009958!RIV/2005/MSM/143105/N
n3:strany
28
n3:aktivita
n16:P
n3:aktivity
P(LN00A016)
n3:dodaniDat
n14:2005
n3:domaciTvurceVysledku
n4:3223779 n4:9031510 n4:7167830 n4:4347374 n4:4585623
n3:druhVysledku
n19:D
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
561485
n3:idVysledku
RIV/00216224:14310/04:00009958
n3:jazykVysledku
n15:slo
n3:klicovaSlova
Molecular dynamics, RNA flexibility, non-Watson-Crick basepair, modular building, long-residency hydration
n3:klicoveSlovo
n8:Molecular%20dynamics n8:long-residency%20hydration n8:RNA%20flexibility n8:modular%20building n8:non-Watson-Crick%20basepair
n3:kontrolniKodProRIV
[686139F44B22]
n3:mistoKonaniAkce
Academic and University Center, Nové Hrady
n3:mistoVydani
Praha
n3:nazevZdroje
Materials Structure in Chemistry, Biology, Physics and Technology
n3:obor
n18:CF
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:projekt
n11:LN00A016
n3:rokUplatneniVysledku
n14:2004
n3:tvurceVysledku
Réblová, Kamila Koča, Jaroslav Leontis, Neocles B. Šponer, Jiří Špačková, Naděžda Rázga, Filip
n3:typAkce
n17:CST
n3:zahajeniAkce
2004-03-11+01:00
s:issn
1211-5894
s:numberOfPages
1
n7:hasPublisher
Krystalografická společnost
n10:organizacniJednotka
14310