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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F03%3A00029121%21RIV10-GA0-14310___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
The global modification of mammalian and plasmid DNAs by novel platinum compounds, cis- or trans-[PtCl2(NH3)(Am)], where Am = NH3, nonplanar heterocycle piperidine, piperazine, or aromatic planar heterocycle 4-picoline, was investigated in cell-free media using various biochemical and biophysical methods. These modifications have been compared with the activity of these new compounds in several tumor cell lines including those resistant to antitumor cis-diamminedichloroplatinum(II) (cisplatin). The results show that the replacement of the NH3 group in cisplatin by the heterocyclic ligands does not considerably affect the DNA binding mode of this drug. Cytotoxicity studies have revealed that the replacement lowers the activity of the platinum compound in both sensitive and resistant cell lines. It has been suggested that the reduced activity of these analogues of cisplatin is associated with some features of the damaged DNA and/or its cellular processing. The global modification of mammalian and plasmid DNAs by novel platinum compounds, cis- or trans-[PtCl2(NH3)(Am)], where Am = NH3, nonplanar heterocycle piperidine, piperazine, or aromatic planar heterocycle 4-picoline, was investigated in cell-free media using various biochemical and biophysical methods. These modifications have been compared with the activity of these new compounds in several tumor cell lines including those resistant to antitumor cis-diamminedichloroplatinum(II) (cisplatin). The results show that the replacement of the NH3 group in cisplatin by the heterocyclic ligands does not considerably affect the DNA binding mode of this drug. Cytotoxicity studies have revealed that the replacement lowers the activity of the platinum compound in both sensitive and resistant cell lines. It has been suggested that the reduced activity of these analogues of cisplatin is associated with some features of the damaged DNA and/or its cellular processing.
dcterms:title
DNA Binding Mode of the Cis and Trans Geometries of New Antitumor Nonclassical Platinum Complexes Containing Piperidine, Piperazine, or 4-Picoline Ligand in Cell-Free Media. Relations to Their Activity in Cancer Cell Lines DNA Binding Mode of the Cis and Trans Geometries of New Antitumor Nonclassical Platinum Complexes Containing Piperidine, Piperazine, or 4-Picoline Ligand in Cell-Free Media. Relations to Their Activity in Cancer Cell Lines
skos:prefLabel
DNA Binding Mode of the Cis and Trans Geometries of New Antitumor Nonclassical Platinum Complexes Containing Piperidine, Piperazine, or 4-Picoline Ligand in Cell-Free Media. Relations to Their Activity in Cancer Cell Lines DNA Binding Mode of the Cis and Trans Geometries of New Antitumor Nonclassical Platinum Complexes Containing Piperidine, Piperazine, or 4-Picoline Ligand in Cell-Free Media. Relations to Their Activity in Cancer Cell Lines
skos:notation
RIV/00216224:14310/03:00029121!RIV10-GA0-14310___
n3:aktivita
n10:Z n10:P
n3:aktivity
P(GA305/01/0418), P(IAA5004101), P(KJB5004301), Z(AV0Z5004920)
n3:cisloPeriodika
20
n3:dodaniDat
n14:2010
n3:domaciTvurceVysledku
n4:7988346 n4:4571932 n4:2087960
n3:druhVysledku
n13:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
604237
n3:idVysledku
RIV/00216224:14310/03:00029121
n3:jazykVysledku
n18:eng
n3:klicovaSlova
platinum complexes; DNA; anticancer
n3:klicoveSlovo
n5:anticancer n5:platinum%20complexes n5:DNA
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[022A82BE15C2]
n3:nazevZdroje
Biochemistry
n3:obor
n15:BO
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n6:GA305%2F01%2F0418 n6:IAA5004101 n6:KJB5004301
n3:rokUplatneniVysledku
n14:2003
n3:svazekPeriodika
42
n3:tvurceVysledku
Marini Palomeque, María Victoria Kašpárková, Jana Najajreh, Yousef Brabec, Viktor Gibson, Dan
n3:zamer
n9:AV0Z5004920
s:issn
0006-2960
s:numberOfPages
12
n19:organizacniJednotka
14310