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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F03%3A00009894%21RIV08-MSM-14310___
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. The conformation of these asymmetric internal loops, called Kink-turns or K-turns, produces sharp, 120-degree bends in both phosphodiester backbones resulting in a V-shaped structure with an acute angle of ca.60 deg. between the RNA helices flanking the motif. In addition, some K-turns are specific binding sites for ribosomal proteins and others take part in RNA-RNA tertiary interactions. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn RNA motifs, including K-turn 38,K-turn 42 and K-turn 58 from the 23S ribosomal RNA of Haloarcula marismortui. The simulations reveal an unprecedented dynamical flexibility, suggesting that K-turn motifs may function as a very flexible internal loops linking rigid helix stems and thus capable of regula Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. The conformation of these asymmetric internal loops, called Kink-turns or K-turns, produces sharp, 120-degree bends in both phosphodiester backbones resulting in a V-shaped structure with an acute angle of ca.60 deg. between the RNA helices flanking the motif. In addition, some K-turns are specific binding sites for ribosomal proteins and others take part in RNA-RNA tertiary interactions. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn RNA motifs, including K-turn 38,K-turn 42 and K-turn 58 from the 23S ribosomal RNA of Haloarcula marismortui. The simulations reveal an unprecedented dynamical flexibility, suggesting that K-turn motifs may function as a very flexible internal loops linking rigid helix stems and thus capable of regula Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. The conformation of these asymmetric internal loops, called Kink-turns or K-turns, produces sharp, 120-degree bends in both phosphodiester backbones resulting in a V-shaped structure with an acute angle of ca.60 deg. between the RNA helices flanking the motif. In addition, some K-turns are specific binding sites for ribosomal proteins and others take part in RNA-RNA tertiary interactions. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn RNA motifs, including K-turn 38,K-turn 42 and K-turn 58 from the 23S ribosomal RNA of Haloarcula marismortui. The simulations reveal an unprecedented dynamical flexibility, suggesting that K-turn motifs may function as a very flexible internal loops linking rigid helix stems and thus capable of regula
dcterms:title
Structure and Dynamics of RNA K-turn Motifs Structure and Dynamics of RNA K-turn Motifs Struktura a dynamika RNA KInk-turn motivov
skos:prefLabel
Structure and Dynamics of RNA K-turn Motifs Struktura a dynamika RNA KInk-turn motivov Structure and Dynamics of RNA K-turn Motifs
skos:notation
RIV/00216224:14310/03:00009894!RIV08-MSM-14310___
n6:strany
21-21
n6:aktivita
n17:P
n6:aktivity
P(LN00A016)
n6:dodaniDat
n11:2008
n6:domaciTvurceVysledku
n15:3223779 n15:4585623 n15:7167830 n15:9031510 n15:4347374
n6:druhVysledku
n18:D
n6:duvernostUdaju
n12:S
n6:entitaPredkladatele
n16:predkladatel
n6:idSjednocenehoVysledku
629231
n6:idVysledku
RIV/00216224:14310/03:00009894
n6:jazykVysledku
n20:eng
n6:klicovaSlova
Molecular Dynamics; non-Watson-Crick basepairs; RNA flexibility
n6:klicoveSlovo
n7:RNA%20flexibility n7:Molecular%20Dynamics n7:non-Watson-Crick%20basepairs
n6:kontrolniKodProRIV
[8C6357CD93BF]
n6:mistoKonaniAkce
Praha
n6:mistoVydani
Praha
n6:nazevZdroje
RNA klub
n6:obor
n9:CF
n6:pocetDomacichTvurcuVysledku
5
n6:pocetTvurcuVysledku
6
n6:projekt
n19:LN00A016
n6:rokUplatneniVysledku
n11:2003
n6:tvurceVysledku
Leontis, Neocles B. Réblová, Kamila Rázga, Filip Koča, Jaroslav Šponer, Jiří Špačková, Naděžda
n6:typAkce
n8:CST
n6:zahajeniAkce
2003-09-25+02:00
s:numberOfPages
1
n4:hasPublisher
Praha
n10:organizacniJednotka
14310