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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F02%3A00036243%21RIV10-MSM-14310___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Development of resistance against metronidazole and mechanisms responsible for this process were studied in a sexually transmitted pathogen of humans, Trichomonas vaginalis. Monitoring of changes in metabolism and protein expression that accompanied increasing resistance of strains derived from a common drug-susceptible parent (TV 10-02) showed the multistep character of the process. The aerobic type of resistance known to occur in isolates from patients non-responsive to treatment appeared at the earliest stage, followed by development of the anaerobic type of resistance which was accompanied by gradual loss of hydrogenosomal proteins associated with drug-activating pathways [pyruvate:ferredoxin oxidoreductase (PFOR), hydrogenase, ferredoxin]. Unexpectedly, the loss of PFOR did not result in acquisition of full anaerobic resistance, thus indicating an alternative source of electrons required for the drug activation. Development of resistance against metronidazole and mechanisms responsible for this process were studied in a sexually transmitted pathogen of humans, Trichomonas vaginalis. Monitoring of changes in metabolism and protein expression that accompanied increasing resistance of strains derived from a common drug-susceptible parent (TV 10-02) showed the multistep character of the process. The aerobic type of resistance known to occur in isolates from patients non-responsive to treatment appeared at the earliest stage, followed by development of the anaerobic type of resistance which was accompanied by gradual loss of hydrogenosomal proteins associated with drug-activating pathways [pyruvate:ferredoxin oxidoreductase (PFOR), hydrogenase, ferredoxin]. Unexpectedly, the loss of PFOR did not result in acquisition of full anaerobic resistance, thus indicating an alternative source of electrons required for the drug activation.
dcterms:title
Mechanisms of in vitro development of resistance to metronidazole in Trichomonas vaginalis Mechanisms of in vitro development of resistance to metronidazole in Trichomonas vaginalis
skos:prefLabel
Mechanisms of in vitro development of resistance to metronidazole in Trichomonas vaginalis Mechanisms of in vitro development of resistance to metronidazole in Trichomonas vaginalis
skos:notation
RIV/00216224:14310/02:00036243!RIV10-MSM-14310___
n4:aktivita
n16:S n16:P n16:Z
n4:aktivity
P(GA204/97/0263), S, Z(MSM 113100003)
n4:cisloPeriodika
8
n4:dodaniDat
n15:2010
n4:domaciTvurceVysledku
n9:5234360
n4:druhVysledku
n11:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n6:predkladatel
n4:idSjednocenehoVysledku
652774
n4:idVysledku
RIV/00216224:14310/02:00036243
n4:jazykVysledku
n13:eng
n4:klicovaSlova
Trichomonas; hydrogenosome; metronidazole; ferredoxin; PFOR; malic enzyme
n4:klicoveSlovo
n8:malic%20enzyme n8:ferredoxin n8:metronidazole n8:hydrogenosome n8:PFOR n8:Trichomonas
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[FC5E7CBBF6EB]
n4:nazevZdroje
Microbiology-UK
n4:obor
n12:CE
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
7
n4:projekt
n10:GA204%2F97%2F0263
n4:rokUplatneniVysledku
n15:2002
n4:svazekPeriodika
148
n4:tvurceVysledku
Vaňáčová, Štěpánka Tomkova, Eva Tachezy, Jan Hrdý, Ivan Kulda, Jaroslav Razga, Jakub Rasoloson, Dominique
n4:wos
000177529800024
n4:zamer
n18:MSM%20113100003
s:issn
1350-0872
s:numberOfPages
11
n19:organizacniJednotka
14310