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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F02%3A00007233%21RIV%2F2003%2FMSM%2F143103%2FN
rdf:type
skos:Concept n14:Vysledek
dcterms:description
The presentation introduce an on-going research project focused on proteins and their interactions with small molecules. Two systems are studied by computer simulations; (1) cyclin-dependent kinase-2 (cdk2) and its inhibition by purine-like compounds, and (2) haloalkane dehalogenases. Cyclin-dependent kinases are enzymes controlling the cell division cycle. A deregulation of cdk has been proved to occur in human primary tumors and in tumor cell lines. It evoked potential application of cdk inhibitors in cancer therapy. Haloalkane dehalogenases are bacterial enzymes cleaving the carbon-halogen bond of the halogenated aliphatic compounds by a hydrolytic mechanism. These enzymes have a potential application in detoxification of subsurface pullutants and recovery of industrial side products. The presentation introduce an on-going research project focused on proteins and their interactions with small molecules. Two systems are studied by computer simulations; (1) cyclin-dependent kinase-2 (cdk2) and its inhibition by purine-like compounds, and (2) haloalkane dehalogenases. Cyclin-dependent kinases are enzymes controlling the cell division cycle. A deregulation of cdk has been proved to occur in human primary tumors and in tumor cell lines. It evoked potential application of cdk inhibitors in cancer therapy. Haloalkane dehalogenases are bacterial enzymes cleaving the carbon-halogen bond of the halogenated aliphatic compounds by a hydrolytic mechanism. These enzymes have a potential application in detoxification of subsurface pullutants and recovery of industrial side products.
dcterms:title
Proteins and Their Interactions With Small Molecules Studied by Computer Simulations. Proteins and Their Interactions With Small Molecules Studied by Computer Simulations.
skos:prefLabel
Proteins and Their Interactions With Small Molecules Studied by Computer Simulations. Proteins and Their Interactions With Small Molecules Studied by Computer Simulations.
skos:notation
RIV/00216224:14310/02:00007233!RIV/2003/MSM/143103/N
n3:strany
45-46
n3:aktivita
n4:Z
n3:aktivity
Z(MSM 143100005)
n3:dodaniDat
n7:2003
n3:domaciTvurceVysledku
n5:4347374 n5:9309616
n3:druhVysledku
n11:D
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
660923
n3:idVysledku
RIV/00216224:14310/02:00007233
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Computer Simulation, Protein, Ligand
n3:klicoveSlovo
n17:Ligand n17:Protein n17:Computer%20Simulation
n3:kontrolniKodProRIV
[5C7231EE6482]
n3:mistoKonaniAkce
Nove Hrady
n3:mistoVydani
Praha
n3:nazevZdroje
Materials Structures in Chemistry, Biology, Physics and Technology
n3:obor
n20:BO
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
5
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:rokUplatneniVysledku
n7:2002
n3:tvurceVysledku
Otyepka, Michal Damborský, Jiří Strnad, Miroslav Koča, Jaroslav Kříž, Zdeněk
n3:typAkce
n12:CST
n3:zahajeniAkce
2002-01-01+01:00
n3:zamer
n6:MSM%20143100005
s:numberOfPages
2
n16:hasPublisher
1. setkani ceskych a slovenskych strukturnich biologu
n18:organizacniJednotka
14310