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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F01%3A00006397%21RIV08-MSM-14310___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Two-fold crystallization of 4-(4-fluorophenyl)-3-hydroxymethyl-1-methyl- piperidine enriched in (+)-enantiomer 3b (65.2-79.4%ee) yielded the racemate that crystallized out of solution and the mother liquor highly enriched in 3b (95.4-97.6% ee). Differences in infrared spectra of the racemate and enantiomer proved that the racemate consists of a racemic compound. Furthermore, solution NMR spectra of enriched 3b showed differentiation of some resonances (self-induced non-equivalence) which indicated strong diastereomeric interactions between solutes in apolar solvent. The enantiomeric composition of products was determined by NMR spectroscopy in the presence of R-Mosher acid. Two-fold crystallization of 4-(4-fluorophenyl)-3-hydroxymethyl-1-methyl- piperidine enriched in (+)-enantiomer 3b (65.2-79.4%ee) yielded the racemate that crystallized out of solution and the mother liquor highly enriched in 3b (95.4-97.6% ee). Differences in infrared spectra of the racemate and enantiomer proved that the racemate consists of a racemic compound. Furthermore, solution NMR spectra of enriched 3b showed differentiation of some resonances (self-induced non-equivalence) which indicated strong diastereomeric interactions between solutes in apolar solvent. The enantiomeric composition of products was determined by NMR spectroscopy in the presence of R-Mosher acid. Two-fold crystallization of 4-(4-fluorophenyl)-3-hydroxymethyl-1-methyl- piperidine enriched in (+)-enantiomer 3b (65.2-79.4%ee) yielded the racemate that crystallized out of solution and the mother liquor highly enriched in 3b (95.4-97.6% ee). Differences in infrared spectra of the racemate and enantiomer proved that the racemate consists of a racemic compound. Furthermore, solution NMR spectra of enriched 3b showed differentiation of some resonances (self-induced non-equivalence) which indicated strong diastereomeric interactions between solutes in apolar solvent. The enantiomeric composition of products was determined by NMR spectroscopy in the presence of R-Mosher acid.
dcterms:title
Enantiomeric enrichment of (+)-(3R,4S)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by crystallization Enantiomeric enrichment of (+)-(3R,4S)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by crystallization Enantiomeric enrichment of (+)-(3R,4S)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by crystallization
skos:prefLabel
Enantiomeric enrichment of (+)-(3R,4S)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by crystallization Enantiomeric enrichment of (+)-(3R,4S)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by crystallization Enantiomeric enrichment of (+)-(3R,4S)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by crystallization
skos:notation
RIV/00216224:14310/01:00006397!RIV08-MSM-14310___
n3:strany
333
n3:aktivita
n12:Z
n3:aktivity
Z(MSM 143100011)
n3:cisloPeriodika
6
n3:dodaniDat
n9:2008
n3:domaciTvurceVysledku
n7:2333368 n7:5305179
n3:druhVysledku
n13:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
679330
n3:idVysledku
RIV/00216224:14310/01:00006397
n3:jazykVysledku
n17:eng
n3:klicovaSlova
enantiomeric enrichment; paroxetine; piperidines; crystalization
n3:klicoveSlovo
n6:enantiomeric%20enrichment n6:piperidines n6:paroxetine n6:crystalization
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[FDEF40D20E42]
n3:nazevZdroje
Enantiomer
n3:obor
n11:CC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n9:2001
n3:svazekPeriodika
6
n3:tvurceVysledku
Potáček, Milan Navrátilová, Hana
n3:zamer
n16:MSM%20143100011
s:issn
1024-2430
s:numberOfPages
6
n18:organizacniJednotka
14310