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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F00%3A00004094%21RIV08-MSM-14310___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Samples of blood and marrow from children with leukemia were assayed for telomerase activity nd expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis, it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, uggesting involvement of a telomerase-independent mechanism of telomere elongation. Samples of blood and marrow from children with leukemia were assayed for telomerase activity nd expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis, it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, uggesting involvement of a telomerase-independent mechanism of telomere elongation. Samples of blood and marrow from children with leukemia were assayed for telomerase activity nd expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis, it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, uggesting involvement of a telomerase-independent mechanism of telomere elongation.
dcterms:title
Telomerase Activity and Expression and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias Telomerase Activity and Expression and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias
skos:prefLabel
Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias Telomerase Activity and Expression and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias Telomerase Activity and Expression and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias
skos:notation
RIV/00216224:14310/00:00004094!RIV08-MSM-14310___
n4:strany
534
n4:aktivita
n6:P n6:Z
n4:aktivity
P(GA301/99/0045), P(IBS5004010), P(VS97032), Z(AV0Z5004920), Z(MSM 143100008), Z(MZ0/98:0001)
n4:cisloPeriodika
5
n4:dodaniDat
n16:2008
n4:domaciTvurceVysledku
n11:4259351 n11:5111951 n11:5004179 n11:8202575 n11:3196178 n11:7753241
n4:druhVysledku
n19:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
728984
n4:idVysledku
RIV/00216224:14310/00:00004094
n4:jazykVysledku
n8:eng
n4:klicovaSlova
acute leukemias; telomerase; in situ analysis of telomeres; chemotherapy; predictive factors
n4:klicoveSlovo
n7:telomerase n7:chemotherapy n7:in%20situ%20analysis%20of%20telomeres n7:acute%20leukemias n7:predictive%20factors
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[EFFEC35DC744]
n4:nazevZdroje
Blood Cells, Molecules and Diseases
n4:obor
n10:FG
n4:pocetDomacichTvurcuVysledku
6
n4:pocetTvurcuVysledku
7
n4:projekt
n15:GA301%2F99%2F0045 n15:IBS5004010 n15:VS97032
n4:rokUplatneniVysledku
n16:2000
n4:svazekPeriodika
26
n4:tvurceVysledku
Bajer, Milan Fajkus, Jiří Skleničková, Marie Hrstková, Hana Krejčí, Kateřina Maláska, Jan Fajkusová, Lenka
n4:zamer
n5:AV0Z5004920 n5:MSM%20143100008 n5:MZ0%2F98%3A0001
s:issn
1079-9796
s:numberOfPages
6
n13:organizacniJednotka
14310