This HTML5 document contains 56 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n11http://localhost/temp/predkladatel/
n9http://linked.opendata.cz/resource/domain/vavai/projekt/
n7http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n6http://linked.opendata.cz/ontology/domain/vavai/
n8http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/
n16http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216224%3A14310%2F00%3A00004094%21RIV%2F2002%2FMSM%2F143102%2FN/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n10http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n19http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n14http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n18http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n15http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F00%3A00004094%21RIV%2F2002%2FMSM%2F143102%2FN
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Samples of blood and marrow from children with leukemia were assayed for telomerase activity nd expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis, it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, uggesting involvement of a telomerase-independent mechanism of telomere elongation. Samples of blood and marrow from children with leukemia were assayed for telomerase activity nd expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis, it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, uggesting involvement of a telomerase-independent mechanism of telomere elongation.
dcterms:title
Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias
skos:prefLabel
Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias
skos:notation
RIV/00216224:14310/00:00004094!RIV/2002/MSM/143102/N
n4:strany
534
n4:aktivita
n5:Z n5:P
n4:aktivity
P(GA301/99/0045), P(VS97032), Z(MSM 143100008)
n4:cisloPeriodika
5
n4:dodaniDat
n15:2002
n4:domaciTvurceVysledku
n7:5004179 n7:8202575 n7:7753241 n7:4259351 n7:3196178 n7:5111951
n4:druhVysledku
n17:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
728983
n4:idVysledku
RIV/00216224:14310/00:00004094
n4:jazykVysledku
n14:eng
n4:klicovaSlova
acute leukemias, telomerase, in situ analysis of telomeres, chemotherapy, predictive factors
n4:klicoveSlovo
n10:acute%20leukemias n10:predictive%20factors n10:in%20situ%20analysis%20of%20telomeres n10:chemotherapy n10:telomerase
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[CBA50A196ECD]
n4:nazevZdroje
Blood Cells, Molecules and Diseases
n4:obor
n18:FG
n4:pocetDomacichTvurcuVysledku
6
n4:pocetTvurcuVysledku
7
n4:pocetUcastnikuAkce
0
n4:pocetZahranicnichUcastnikuAkce
0
n4:projekt
n9:GA301%2F99%2F0045 n9:VS97032
n4:rokUplatneniVysledku
n15:2000
n4:svazekPeriodika
26
n4:tvurceVysledku
Krejčí, Kateřina Hrstková, Hana Bajer, Milan Fajkus, Jiří Fajkusová, Lenka Maláska, Jan Skleničková, Marie
n4:zamer
n8:MSM%20143100008
s:issn
1079-9796
s:numberOfPages
6
n11:organizacniJednotka
14310