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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F00%3A00002452%21RIV08-MSM-14310___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
Samples of blood and marrow from children with leukemia were assayed for telomerase activity and expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis; it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, suggesting involvement of a telomerase-independent mechanism of telomere elongation. Samples of blood and marrow from children with leukemia were assayed for telomerase activity and expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis; it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, suggesting involvement of a telomerase-independent mechanism of telomere elongation. Samples of blood and marrow from children with leukemia were assayed for telomerase activity and expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis; it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, suggesting involvement of a telomerase-independent mechanism of telomere elongation.
dcterms:title
Telomerase activity and expression in the course of treatment of acute childhood leukemias Telomerase activity and expression in the course of treatment of acute childhood leukemias Telomerase activity and expression in the course of treatment of acute childhood leukemias
skos:prefLabel
Telomerase activity and expression in the course of treatment of acute childhood leukemias Telomerase activity and expression in the course of treatment of acute childhood leukemias Telomerase activity and expression in the course of treatment of acute childhood leukemias
skos:notation
RIV/00216224:14310/00:00002452!RIV08-MSM-14310___
n5:strany
29a
n5:aktivita
n18:Z n18:P
n5:aktivity
P(GA301/99/0045), P(VS97032), Z(MSM 143100008)
n5:dodaniDat
n7:2008
n5:domaciTvurceVysledku
n6:5111951 n6:7753241 n6:3196178 n6:2912589 n6:6522319 n6:4259351 n6:5004179 n6:9863737 n6:8202575 n6:3614107
n5:druhVysledku
n21:D
n5:duvernostUdaju
n17:S
n5:entitaPredkladatele
n13:predkladatel
n5:idSjednocenehoVysledku
728985
n5:idVysledku
RIV/00216224:14310/00:00002452
n5:jazykVysledku
n8:eng
n5:klicovaSlova
Telomerase activity
n5:klicoveSlovo
n12:Telomerase%20activity
n5:kontrolniKodProRIV
[CDDB59E230ED]
n5:mistoKonaniAkce
Miami Florida USA
n5:mistoVydani
Oxford
n5:nazevZdroje
Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER
n5:obor
n15:EB
n5:pocetDomacichTvurcuVysledku
10
n5:pocetTvurcuVysledku
10
n5:projekt
n9:GA301%2F99%2F0045 n9:VS97032
n5:rokUplatneniVysledku
n7:2000
n5:tvurceVysledku
Skleničková, Marie Hrstková, Hana Fajkus, Jiří Maláska, Jan Bajer, Milan Vyzula, Rostislav Krejčí, Kateřina Bajerová, Kateřina Fajkusová, Lenka Michálek, Jaroslav
n5:typAkce
n10:CST
n5:zahajeniAkce
2000-01-01+01:00
n5:zamer
n14:MSM%20143100008
s:issn
1087-0156
s:numberOfPages
1
n16:hasPublisher
Oxford University Press
n20:organizacniJednotka
14310