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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F99%3A00002134%21RIV09-GA0-14110___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Associations among five gene polymorphism interactions and clinically manifested psoriasis were studied. All studied gene polymorphisms (endothelin-1-ET-1, transporters associated with antigen processing-TAP1, tumor necrosis factor beta-TNF beta, angiotensin I converting enzyme-ACE, advanced glycosylation end product-specific receptor- RAGE) were analyzed for their possible participation in the MHC class I cell surface antigen presentation to CD8+ T-cells. In psoriatic patients (n=153), the disequilibrium was found for coincidence of TNF beta with TAPl-333 ( P=0.016) as well as with TAP1-637 ( P=0.035). TNF beta was in disequilibrium with (ACE) polymorphism (P=0.036). ACE was observed to be in tight disequilibrium with TAP1-333 (p= 0.009) but not with TAP1-637 (P=0.133). The borderline significance of disequilibrium was found for ET-1 and RAGE gene polymorphisms (P=0.07). Associations among five gene polymorphism interactions and clinically manifested psoriasis were studied. All studied gene polymorphisms (endothelin-1-ET-1, transporters associated with antigen processing-TAP1, tumor necrosis factor beta-TNF beta, angiotensin I converting enzyme-ACE, advanced glycosylation end product-specific receptor- RAGE) were analyzed for their possible participation in the MHC class I cell surface antigen presentation to CD8+ T-cells. In psoriatic patients (n=153), the disequilibrium was found for coincidence of TNF beta with TAPl-333 ( P=0.016) as well as with TAP1-637 ( P=0.035). TNF beta was in disequilibrium with (ACE) polymorphism (P=0.036). ACE was observed to be in tight disequilibrium with TAP1-333 (p= 0.009) but not with TAP1-637 (P=0.133). The borderline significance of disequilibrium was found for ET-1 and RAGE gene polymorphisms (P=0.07). Associations among five gene polymorphism interactions and clinically manifested psoriasis were studied. All studied gene polymorphisms (endothelin-1-ET-1, transporters associated with antigen processing-TAP1, tumor necrosis factor beta-TNF beta, angiotensin I converting enzyme-ACE, advanced glycosylation end product-specific receptor- RAGE) were analyzed for their possible participation in the MHC class I cell surface antigen presentation to CD8+ T-cells. In psoriatic patients (n=153), the disequilibrium was found for coincidence of TNF beta with TAPl-333 ( P=0.016) as well as with TAP1-637 ( P=0.035). TNF beta was in disequilibrium with (ACE) polymorphism (P=0.036). ACE was observed to be in tight disequilibrium with TAP1-333 (p= 0.009) but not with TAP1-637 (P=0.133). The borderline significance of disequilibrium was found for ET-1 and RAGE gene polymorphisms (P=0.07).
dcterms:title
Interaction of five gene polymorphism at psoriasis Interaction of five gene polymorphism at psoriasis Interaction of five gene polymorphism at psoriasis
skos:prefLabel
Interaction of five gene polymorphism at psoriasis Interaction of five gene polymorphism at psoriasis Interaction of five gene polymorphism at psoriasis
skos:notation
RIV/00216224:14110/99:00002134!RIV09-GA0-14110___
n3:aktivita
n17:P n17:Z
n3:aktivity
P(GA306/93/2192), P(GA306/96/0099), P(VS96097), Z(MSM 141100002)
n3:cisloPeriodika
3
n3:dodaniDat
n14:2009
n3:domaciTvurceVysledku
n4:7603622 n4:8430322 n4:9688498 n4:1730908 n4:7988788 n4:8832242 n4:6918115
n3:druhVysledku
n18:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
742975
n3:idVysledku
RIV/00216224:14110/99:00002134
n3:jazykVysledku
n12:eng
n3:klicovaSlova
gene; polymorphism; TAP; TNF; endothelin; ACE
n3:klicoveSlovo
n6:TNF n6:gene n6:ACE n6:endothelin n6:polymorphism n6:TAP
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[65D50760B29E]
n3:nazevZdroje
The Journal of Investigative Dermatology
n3:obor
n16:FO
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n9:GA306%2F93%2F2192 n9:GA306%2F96%2F0099 n9:VS96097
n3:rokUplatneniVysledku
n14:1999
n3:svazekPeriodika
113
n3:tvurceVysledku
Semrádová, Věra Znojil, Vladimír Kaňková, Kateřina Vašků, Anna Vácha, Jiří Vašků, Vladimír Izakovičová-Hollá, Lydie
n3:wos
000082406000405
n3:zamer
n13:MSM%20141100002
s:issn
0022-202X
s:numberOfPages
1
n11:organizacniJednotka
14110