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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F99%3A00001308%21RIV%2F2002%2FGA0%2F141102%2FN
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Propafenone, a class I antiarrhythmic agent, inhibits several membrane currents, however, its effect on ATP-sensitive potassium current (IKATP) of cerdiac cells have not been tested. We evaluated the blocking effect of 0.1 to 100 uM propafenone on the whole cell IKATP as triggered by dinitrophenol in aduld rabbit isolated atrial and ventricular cardiomyocytes. It is concluded that propafenone blocks cardiac IKATP at a single site. This block might play a role in the beneficial and adverse effects of the drug. Propafenone, a class I antiarrhythmic agent, inhibits several membrane currents, however, its effect on ATP-sensitive potassium current (IKATP) of cerdiac cells have not been tested. We evaluated the blocking effect of 0.1 to 100 uM propafenone on the whole cell IKATP as triggered by dinitrophenol in aduld rabbit isolated atrial and ventricular cardiomyocytes. It is concluded that propafenone blocks cardiac IKATP at a single site. This block might play a role in the beneficial and adverse effects of the drug.
dcterms:title
Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes. Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes.
skos:prefLabel
Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes. Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes.
skos:notation
RIV/00216224:14110/99:00001308!RIV/2002/GA0/141102/N
n4:strany
223
n4:aktivita
n12:P
n4:aktivity
P(GA305/97/0043)
n4:cisloPeriodika
2-3
n4:dodaniDat
n8:2002
n4:domaciTvurceVysledku
n6:1722026 n6:7773625
n4:druhVysledku
n9:J
n4:duvernostUdaju
n5:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
751482
n4:idVysledku
RIV/00216224:14110/99:00001308
n4:jazykVysledku
n14:eng
n4:klicovaSlova
Antiarrhythmic; Propafenone; K+ channel; ATP-sensitive; Cardiomyocyte; Ventricle.
n4:klicoveSlovo
n7:Cardiomyocyte n7:Ventricle. n7:Propafenone n7:K%2B%20channel n7:ATP-sensitive n7:Antiarrhythmic
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[EA05C5146810]
n4:nazevZdroje
European Journal of Pharmacology
n4:obor
n15:ED
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
5
n4:pocetUcastnikuAkce
0
n4:pocetZahranicnichUcastnikuAkce
0
n4:projekt
n11:GA305%2F97%2F0043
n4:rokUplatneniVysledku
n8:1999
n4:svazekPeriodika
373
n4:tvurceVysledku
Šimurda, Jiří Šimurdová, Milena Forrat, Rémi Christé, Georg Tebbakh, Habiba
s:issn
0014-2999
s:numberOfPages
10
n16:organizacniJednotka
14110