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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F98%3A00003839%21RIV%2F2002%2FMZ0%2F141102%2FN
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Chronic childhood idiopathic (immune) thrombocytopenic purpura (ITP) is relatively rare, accounting only for 10-20% of children with ITP. Its treatment is very difficult. The therapeutic modalities are the following: steroids (high-dose or pulse therapy, high-dose immunoblobulin, interferon, anti-D immunoglobulin, cytotoxic immunosuppressives (azathioprine), splenectomy, etc. A group of 37 children with chronic ITP was treated during the last ten years in the First Department of Pediatrics. We used all above-mentioned curative options except of anti-D immunoglobulin. The permanent increase of the platelet count over 10x10/9/l as most often reached after splenectomy (11 children), cytotoxic immunosuppressives (4 children), steroids (2 children) and interferonu alpha 2a (2 children). The 2 children treated with interferon had even the permanent platelet count above 150x10/9/l. Regarding the undesireble side-effects of some therapy (splenectomy, storoids, cytotoxic immunosuppressives), we recomend to use Chronic childhood idiopathic (immune) thrombocytopenic purpura (ITP) is relatively rare, accounting only for 10-20% of children with ITP. Its treatment is very difficult. The therapeutic modalities are the following: steroids (high-dose or pulse therapy, high-dose immunoblobulin, interferon, anti-D immunoglobulin, cytotoxic immunosuppressives (azathioprine), splenectomy, etc. A group of 37 children with chronic ITP was treated during the last ten years in the First Department of Pediatrics. We used all above-mentioned curative options except of anti-D immunoglobulin. The permanent increase of the platelet count over 10x10/9/l as most often reached after splenectomy (11 children), cytotoxic immunosuppressives (4 children), steroids (2 children) and interferonu alpha 2a (2 children). The 2 children treated with interferon had even the permanent platelet count above 150x10/9/l. Regarding the undesireble side-effects of some therapy (splenectomy, storoids, cytotoxic immunosuppressives), we recomend to use
dcterms:title
Results of treatment of childhood chronic ITP Results of treatment of childhood chronic ITP
skos:prefLabel
Results of treatment of childhood chronic ITP Results of treatment of childhood chronic ITP
skos:notation
RIV/00216224:14110/98:00003839!RIV/2002/MZ0/141102/N
n3:strany
39
n3:aktivita
n18:P
n3:aktivity
P(IZ3710)
n3:cisloPeriodika
1
n3:dodaniDat
n5:2002
n3:domaciTvurceVysledku
n12:4259351 n12:5004179
n3:druhVysledku
n4:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
782490
n3:idVysledku
RIV/00216224:14110/98:00003839
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Results of treatment of childhood chronic ITP
n3:klicoveSlovo
n10:Results%20of%20treatment%20of%20childhood%20chronic%20ITP
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[FB840A47EEBF]
n3:nazevZdroje
Scripta medica
n3:obor
n11:FG
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n13:IZ3710
n3:rokUplatneniVysledku
n5:1998
n3:svazekPeriodika
71
n3:tvurceVysledku
Bajer, Milan Hrstková, Hana
s:issn
1211-3395
s:numberOfPages
10
n14:organizacniJednotka
14110