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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00078991%21RIV15-MSM-14110___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Background: Children with high-grade glioma still have a poor prognosis despite the use of multimodal therapy including surgery, radiotherapy, and chemotherapy. New therapeutic strategies and methods evaluating such therapies are needed. Observation: Here we describe a child with anaplastic oligodendroglioma of the spinal cord who was unable to tolerate standard chemoradiotherapy and who had still-vital residual tumour during therapy. A good response was obtained with low-dose metronomic treatment containing vinblastine. The treatment was guided according to gradual response assessed using various positron-emission tomography tracers. Conclusions: Metronomic treatment guided by positron-emission tomography could be a reasonable option in some high-risk pediatric tumours. Background: Children with high-grade glioma still have a poor prognosis despite the use of multimodal therapy including surgery, radiotherapy, and chemotherapy. New therapeutic strategies and methods evaluating such therapies are needed. Observation: Here we describe a child with anaplastic oligodendroglioma of the spinal cord who was unable to tolerate standard chemoradiotherapy and who had still-vital residual tumour during therapy. A good response was obtained with low-dose metronomic treatment containing vinblastine. The treatment was guided according to gradual response assessed using various positron-emission tomography tracers. Conclusions: Metronomic treatment guided by positron-emission tomography could be a reasonable option in some high-risk pediatric tumours.
dcterms:title
Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child
skos:prefLabel
Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child
skos:notation
RIV/00216224:14110/14:00078991!RIV15-MSM-14110___
n3:aktivita
n15:P
n3:aktivity
P(ED2.1.00/03.0101), P(LM2011017)
n3:cisloPeriodika
6
n3:dodaniDat
n10:2015
n3:domaciTvurceVysledku
n13:3588998 n13:7248857 n13:1398954 n13:7064934 n13:5414377 n13:3503216
n3:druhVysledku
n14:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
48496
n3:idVysledku
RIV/00216224:14110/14:00078991
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Biomarkers; Metronomic chemotherapy; Pediatric glioma; PET imaging; Vinblastine
n3:klicoveSlovo
n5:PET%20imaging n5:Metronomic%20chemotherapy n5:Pediatric%20glioma n5:Biomarkers n5:Vinblastine
n3:kodStatuVydavatele
CA - Kanada
n3:kontrolniKodProRIV
[F5676AB1E5CE]
n3:nazevZdroje
Current Oncology
n3:obor
n16:FD
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n4:ED2.1.00%2F03.0101 n4:LM2011017
n3:rokUplatneniVysledku
n10:2014
n3:svazekPeriodika
21
n3:tvurceVysledku
Demlová, Regina Řehák, Zdeněk Melichárková, Kristýna Štěrba, Jaroslav Ošlejšková, Hana Křen, Leoš
n3:wos
000348599900008
s:issn
1198-0052
s:numberOfPages
4
n19:doi
10.3747/co.21.2147
n11:organizacniJednotka
14110