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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00078340%21RIV15-MSM-14110___
rdf:type
skos:Concept n10:Vysledek
dcterms:description
Mutations in the BCR-ABL1 kinase domain (KD) represent one of the most important causes of resistance to tyrosine kinase inhibitors (TKIs) treatment in patients with chronic myeloid leukemia (CML). The resistance-causing mutations are hypothesized to expand directly from the stem and/or progenitor cells and are present in CD341 cells significantly earlier than they occur in bone marrow or peripheral blood. Thus, early detection of these mutations is of great importance, since it can affect the subsequent TKI therapy. Mutations in the BCR-ABL1 kinase domain (KD) represent one of the most important causes of resistance to tyrosine kinase inhibitors (TKIs) treatment in patients with chronic myeloid leukemia (CML). The resistance-causing mutations are hypothesized to expand directly from the stem and/or progenitor cells and are present in CD341 cells significantly earlier than they occur in bone marrow or peripheral blood. Thus, early detection of these mutations is of great importance, since it can affect the subsequent TKI therapy.
dcterms:title
BCR-ABL1 kinase domain mutational analysis of CD34+ stem/progenitor cells in newly diagnosed CML patients by next-generation sequencing BCR-ABL1 kinase domain mutational analysis of CD34+ stem/progenitor cells in newly diagnosed CML patients by next-generation sequencing
skos:prefLabel
BCR-ABL1 kinase domain mutational analysis of CD34+ stem/progenitor cells in newly diagnosed CML patients by next-generation sequencing BCR-ABL1 kinase domain mutational analysis of CD34+ stem/progenitor cells in newly diagnosed CML patients by next-generation sequencing
skos:notation
RIV/00216224:14110/14:00078340!RIV15-MSM-14110___
n3:aktivita
n9:P
n3:aktivity
P(EE2.3.30.0037)
n3:cisloPeriodika
10
n3:dodaniDat
n6:2015
n3:domaciTvurceVysledku
n5:4585623 n5:4294521 n5:4376285 n5:1344153 n5:5378605 n5:4310683 n5:3715434 n5:3004880
n3:druhVysledku
n19:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
4943
n3:idVysledku
RIV/00216224:14110/14:00078340
n3:jazykVysledku
n12:eng
n3:klicovaSlova
BCR-ABL; CD34+; CML; next generation sequencing
n3:klicoveSlovo
n8:CD34%2B n8:next%20generation%20sequencing n8:BCR-ABL n8:CML
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[884A2821D9C4]
n3:nazevZdroje
American Journal of Hematology
n3:obor
n11:FD
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
11
n3:projekt
n13:EE2.3.30.0037
n3:rokUplatneniVysledku
n6:2014
n3:svazekPeriodika
89
n3:tvurceVysledku
Ráčil, Zdeněk Žáčková, Daniela Čulen, Martin Jurček, Tomáš Mayer, Jiří Rázga, Filip Ježíšková, Ivana Borský, Marek Dvořáková, Dana Némethová, Veronika Musilová, Milena
n3:wos
000342689200021
s:issn
0361-8609
s:numberOfPages
2
n15:doi
10.1002/ajh.23794
n17:organizacniJednotka
14110