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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00078029%21RIV15-MSM-14110___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Genetic and non-genetic predictors of 15-year survival in patients with chronic three-vessel disease (3VD) were investigated. Coronary angiography was performed on 810 subjects with symptoms of stable ischemic heart disease in 1998. The patients with 3VD were genotyped for 23 candidate polymorphisms covering the PPAR-RXR pathway, matrix metalloproteinase-2, renin-angiotensin-aldosterone system, endothelin-1, cytokine genes, MTHFR and APO E variants. Fifteen-year survival data were obtained from the national insurance registry. All data were available in the case of 150 patients with 3VD. Statistical analysis used stepwise Cox regression with dominant, recessive, or additive mode of genetic expression. Involved variables included age, sex, BMI, blood pressure, diabetes, ejection fraction, left main stenosis, previously diagnosed coronary stenosis, myocardial infarction in personal history, and coronary bypass along with polymorphisms pre-selected by log-rank tests. Genetic and non-genetic predictors of 15-year survival in patients with chronic three-vessel disease (3VD) were investigated. Coronary angiography was performed on 810 subjects with symptoms of stable ischemic heart disease in 1998. The patients with 3VD were genotyped for 23 candidate polymorphisms covering the PPAR-RXR pathway, matrix metalloproteinase-2, renin-angiotensin-aldosterone system, endothelin-1, cytokine genes, MTHFR and APO E variants. Fifteen-year survival data were obtained from the national insurance registry. All data were available in the case of 150 patients with 3VD. Statistical analysis used stepwise Cox regression with dominant, recessive, or additive mode of genetic expression. Involved variables included age, sex, BMI, blood pressure, diabetes, ejection fraction, left main stenosis, previously diagnosed coronary stenosis, myocardial infarction in personal history, and coronary bypass along with polymorphisms pre-selected by log-rank tests.
dcterms:title
Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival. Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival.
skos:prefLabel
Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival. Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival.
skos:notation
RIV/00216224:14110/14:00078029!RIV15-MSM-14110___
n3:aktivita
n14:P
n3:aktivity
P(ED1.100/02/0123), P(VS96097)
n3:cisloPeriodika
28
n3:dodaniDat
n13:2015
n3:domaciTvurceVysledku
n8:9688498 n8:3395820 n8:8680876
n3:druhVysledku
n12:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
35922
n3:idVysledku
RIV/00216224:14110/14:00078029
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Atherosclerosis; genetic factors; interleukin 6; survival analysis; three vessel disease
n3:klicoveSlovo
n4:genetic%20factors n4:three%20vessel%20disease n4:interleukin%206 n4:survival%20analysis n4:Atherosclerosis
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[827A1F54DDE2]
n3:nazevZdroje
Medicine
n3:obor
n19:FA
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n11:VS96097 n11:ED1.100%2F02%2F0123
n3:rokUplatneniVysledku
n13:2014
n3:svazekPeriodika
93
n3:tvurceVysledku
Groch, Ladislav Vašků, Anna Máchal, Jan Pávková Goldbergová, Monika Hlinomaz, Ota
n3:wos
000346762200030
s:issn
0025-7974
s:numberOfPages
9
n18:doi
10.1097/MD.0000000000000278
n17:organizacniJednotka
14110