This HTML5 document contains 46 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n12http://localhost/temp/predkladatel/
n6http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n18http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216224%3A14110%2F14%3A00077503%21RIV15-MSM-14110___/
n3http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/
n16http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n7http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n14http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n11http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n13http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n10http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n5http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00077503%21RIV15-MSM-14110___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Purpose Common variable immunodeficiency (CVID) is the most frequent form of primary symptomatic hypogammaglobulinemia. CVID patients display a number of abnormalities in lymphocyte subpopulations including chronic T-cell activation and decreased numbers of circulating CD4+ T cells and NK cells. We and others have recently shown that CVID is associated with increased concentration of soluble CD14 (sCD14) and other factors indicating limited microbial translocation. Methods To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of cytokine serum levels in 36 patients with CVID, 52 patients with selective IgA deficiency (IgAD), and 56 healthy volunteers. Results We show that CVID is associated with elevated serum levels of CXCL-10/IP-10, IL-1R antagonist, TNF-alpha, IL-10, IL-12 (p40), CCL-2/MCP-1, G-CSF, and CCL-11/eotaxin. The detected cytokine signature is consistent with an ongoing activation of cells of myeloid lineage. Purpose Common variable immunodeficiency (CVID) is the most frequent form of primary symptomatic hypogammaglobulinemia. CVID patients display a number of abnormalities in lymphocyte subpopulations including chronic T-cell activation and decreased numbers of circulating CD4+ T cells and NK cells. We and others have recently shown that CVID is associated with increased concentration of soluble CD14 (sCD14) and other factors indicating limited microbial translocation. Methods To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of cytokine serum levels in 36 patients with CVID, 52 patients with selective IgA deficiency (IgAD), and 56 healthy volunteers. Results We show that CVID is associated with elevated serum levels of CXCL-10/IP-10, IL-1R antagonist, TNF-alpha, IL-10, IL-12 (p40), CCL-2/MCP-1, G-CSF, and CCL-11/eotaxin. The detected cytokine signature is consistent with an ongoing activation of cells of myeloid lineage.
dcterms:title
Altered Serum Cytokine Signature in Common Variable Immunodeficiency Altered Serum Cytokine Signature in Common Variable Immunodeficiency
skos:prefLabel
Altered Serum Cytokine Signature in Common Variable Immunodeficiency Altered Serum Cytokine Signature in Common Variable Immunodeficiency
skos:notation
RIV/00216224:14110/14:00077503!RIV15-MSM-14110___
n4:aktivita
n14:I
n4:aktivity
I
n4:cisloPeriodika
8
n4:dodaniDat
n5:2015
n4:domaciTvurceVysledku
n6:9731490 n6:4110285 n6:1027530
n4:druhVysledku
n10:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
2246
n4:idVysledku
RIV/00216224:14110/14:00077503
n4:jazykVysledku
n11:eng
n4:klicovaSlova
Common variable immunodeficiency; IgA deficiency; cytokine; lymphocyte activation
n4:klicoveSlovo
n7:lymphocyte%20activation n7:cytokine n7:Common%20variable%20immunodeficiency n7:IgA%20deficiency
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[A514A9A1602B]
n4:nazevZdroje
Journal of Clinical Immunology
n4:obor
n13:EC
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
6
n4:rokUplatneniVysledku
n5:2014
n4:svazekPeriodika
34
n4:tvurceVysledku
Nechvátalová, Jana Litzman, Jiří Vlková, Marcela Huijbregts, Richard P. H. Xu, Jun Hel, Zdenek
n4:wos
000344780000012
s:issn
0271-9142
s:numberOfPages
8
n16:doi
10.1007/s10875-014-0099-z
n12:organizacniJednotka
14110