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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00077328%21RIV15-MSM-14110___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Dendritic cells (DCs) belong to the immune system and are particularly studied for their potential to direct either an activated or tolerogenic immune response. The roles of microRNAs (miRNAs) in posttranscriptional gene expression regulation are being increasingly investigated. This study's aim is to evaluate the miRNAs' expression changes in prepared human immature (iDCs), activated (aDCs), and tolerogenic dendritic cells (tDCs). The dendritic cells were prepared using GM-CSF and IL-4 (iDC) and subsequently maturated by adding LPS and IFN-gamma(aDC) or IL-10 and TGF-beta(tDC). Surface markers, cytokine profiles, and miRNA profiles were evaluated in iDC, tDC, and aDC at 6 h and 24 h of maturation. We identified 4 miRNAs (miR-7, miR-9, miR-155 and miR-182), which were consistently overexpressed in aDC after 6 h and 24 h of maturation and 3 miRNAs (miR-17, miR-133b, and miR-203) and miR-23b cluster solely expressed in tDC. Dendritic cells (DCs) belong to the immune system and are particularly studied for their potential to direct either an activated or tolerogenic immune response. The roles of microRNAs (miRNAs) in posttranscriptional gene expression regulation are being increasingly investigated. This study's aim is to evaluate the miRNAs' expression changes in prepared human immature (iDCs), activated (aDCs), and tolerogenic dendritic cells (tDCs). The dendritic cells were prepared using GM-CSF and IL-4 (iDC) and subsequently maturated by adding LPS and IFN-gamma(aDC) or IL-10 and TGF-beta(tDC). Surface markers, cytokine profiles, and miRNA profiles were evaluated in iDC, tDC, and aDC at 6 h and 24 h of maturation. We identified 4 miRNAs (miR-7, miR-9, miR-155 and miR-182), which were consistently overexpressed in aDC after 6 h and 24 h of maturation and 3 miRNAs (miR-17, miR-133b, and miR-203) and miR-23b cluster solely expressed in tDC.
dcterms:title
MicroRNA profiling of activated and tolerogenic human dendritic cells MicroRNA profiling of activated and tolerogenic human dendritic cells
skos:prefLabel
MicroRNA profiling of activated and tolerogenic human dendritic cells MicroRNA profiling of activated and tolerogenic human dendritic cells
skos:notation
RIV/00216224:14110/14:00077328!RIV15-MSM-14110___
n3:aktivita
n18:P
n3:aktivity
P(ED1.1.00/02.0068), P(NT13514), P(NT13547)
n3:cisloPeriodika
259689
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n11:7022484 n11:7179030 n11:6522319 n11:5974291 n11:8285721
n3:druhVysledku
n17:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
29207
n3:idVysledku
RIV/00216224:14110/14:00077328
n3:jazykVysledku
n8:eng
n3:klicovaSlova
microRNA; dendritic cells; expression profiling
n3:klicoveSlovo
n6:expression%20profiling n6:microRNA n6:dendritic%20cells
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[AF209607CEB8]
n3:nazevZdroje
Mediators of Inflammation
n3:obor
n4:EC
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n13:ED1.1.00%2F02.0068 n13:NT13547 n13:NT13514
n3:rokUplatneniVysledku
n7:2014
n3:svazekPeriodika
2014
n3:tvurceVysledku
Héžová, Renata Michálek, Jaroslav Meli, Albano Slabý, Ondřej Štumpfová, Zuzana
n3:wos
000334283100001
s:issn
0962-9351
s:numberOfPages
10
n19:doi
10.1155/2014/259689
n9:organizacniJednotka
14110