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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00077103%21RIV15-MSM-14110___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer next to hepatocellular carcinoma (HCC). Despite the significant difference of the therapeutic strategy for both diseases, their histological appearance may be very similar. Thus the correct diagnosis is crucial for treatment choice but is often difficult to achieve. The aim of our study was to evaluate anterior gradient 3 (AGR3) as a new diagnostic marker helping to distinguish between ICC and HCC. AGR3 is a putative transmembrane protein implicated in breast, prostate and ovary tumorigenesis and belongs to the family of protein disulfide isomerases. Since there is little information on how AGR3 is expressed in normal and diseased tissues and what its exact function is, we analyzed its expression pattern in normal liver and tumor tissue of ICC and HCC. The immunohistochemical analysis in normal tissue revealed specific AGR3 expression in intrahepatic bile duct cholangiocytes which was not present in liver hepatocytes. Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer next to hepatocellular carcinoma (HCC). Despite the significant difference of the therapeutic strategy for both diseases, their histological appearance may be very similar. Thus the correct diagnosis is crucial for treatment choice but is often difficult to achieve. The aim of our study was to evaluate anterior gradient 3 (AGR3) as a new diagnostic marker helping to distinguish between ICC and HCC. AGR3 is a putative transmembrane protein implicated in breast, prostate and ovary tumorigenesis and belongs to the family of protein disulfide isomerases. Since there is little information on how AGR3 is expressed in normal and diseased tissues and what its exact function is, we analyzed its expression pattern in normal liver and tumor tissue of ICC and HCC. The immunohistochemical analysis in normal tissue revealed specific AGR3 expression in intrahepatic bile duct cholangiocytes which was not present in liver hepatocytes.
dcterms:title
Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma. Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma.
skos:prefLabel
Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma. Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma.
skos:notation
RIV/00216224:14110/14:00077103!RIV15-MSM-14110___
n3:aktivita
n9:I
n3:aktivity
I
n3:cisloPeriodika
3
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
n5:2299690 n5:6670199
n3:druhVysledku
n10:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
11485
n3:idVysledku
RIV/00216224:14110/14:00077103
n3:jazykVysledku
n18:eng
n3:klicovaSlova
AGR3; GPC-3; Intrahepatic cholangiocarcinoma; Hepatocellular carcinoma; Mucopolysaccharides; Immunohistochemistry
n3:klicoveSlovo
n4:Hepatocellular%20carcinoma n4:GPC-3 n4:Intrahepatic%20cholangiocarcinoma n4:Mucopolysaccharides n4:AGR3 n4:Immunohistochemistry
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[44F7B8C6AC02]
n3:nazevZdroje
Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma
n3:obor
n16:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n8:2014
n3:svazekPeriodika
96
n3:tvurceVysledku
Novák, Jiří Hermanová, Markéta Žampachová, Víta Brychtová, Veronika Vojtěšek, Bořivoj Hrstka, Roman Fabian, Pavel
n3:wos
000337212600016
s:issn
0014-4800
s:numberOfPages
7
n7:doi
10.1016/j.yexmp.2014.04.002
n12:organizacniJednotka
14110