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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00076812%21RIV15-MSM-14110___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Background Differences exist between the proximal and distal colon in terms of developmental origin, exposure to patterning genes, environmental mutagens and gut flora. Little is known on how these differences may affect mechanisms of tumorigenesis, side specific therapy response or prognosis. We explored systematic differences in pathway activation and their clinical implications. Materials and Methods Detailed clinico-pathological data for 3045 colon carcinoma patients enrolled in the PETACC3 adjuvant chemotherapy trial were available for analysis. A subset of 1404 samples had molecular data, including gene expression and DNA copy number profiles for 589 and 199 samples, respectively. In addition, 413 colon adenocarcinoma from TCGA collection were also analyzed. Tumor side effect on anti-EGFR therapy was assessed in a cohort of 325 metastatic patients. Outcome variables considered were relapse-free survival (RFS) and survival after relapse (SAR). Background Differences exist between the proximal and distal colon in terms of developmental origin, exposure to patterning genes, environmental mutagens and gut flora. Little is known on how these differences may affect mechanisms of tumorigenesis, side specific therapy response or prognosis. We explored systematic differences in pathway activation and their clinical implications. Materials and Methods Detailed clinico-pathological data for 3045 colon carcinoma patients enrolled in the PETACC3 adjuvant chemotherapy trial were available for analysis. A subset of 1404 samples had molecular data, including gene expression and DNA copy number profiles for 589 and 199 samples, respectively. In addition, 413 colon adenocarcinoma from TCGA collection were also analyzed. Tumor side effect on anti-EGFR therapy was assessed in a cohort of 325 metastatic patients. Outcome variables considered were relapse-free survival (RFS) and survival after relapse (SAR).
dcterms:title
Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features
skos:prefLabel
Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features
skos:notation
RIV/00216224:14110/14:00076812!RIV15-MSM-14110___
n3:aktivita
n4:I
n3:aktivity
I
n3:cisloPeriodika
10
n3:dodaniDat
n11:2015
n3:domaciTvurceVysledku
n13:4977203 n13:3818780
n3:druhVysledku
n17:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
11788
n3:idVysledku
RIV/00216224:14110/14:00076812
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Colon cancer; Expression profiling; Mutations; Oncogenic pathways; Survival
n3:klicoveSlovo
n6:Expression%20profiling n6:Survival n6:Colon%20cancer n6:Mutations n6:Oncogenic%20pathways
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[3BACFF87BB4B]
n3:nazevZdroje
Annals of Oncology
n3:obor
n10:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
15
n3:rokUplatneniVysledku
n11:2014
n3:svazekPeriodika
25
n3:tvurceVysledku
Vecchione, L. Roth, Arnaud Tejpar, S. Yan, P. Missiaglia, E. D´Ario, G. Popovici, Vlad Klingbiel, D. Gerster, S. Bosman, F.T. Budinská, Eva Delorenzi, M. Soneson, C. Di Narzo, A. F. Jacobs, B.
n3:wos
000343045500017
s:issn
0923-7534
s:numberOfPages
8
n5:doi
10.1093/annonc/mdu275
n18:organizacniJednotka
14110