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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00076568%21RIV15-MSM-14110___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Zinc(II) ions are important components of many proteins and are involved in numerous cellular processes such as apoptosis or drug resistance. Prostate cancer has a unique relationship with zinc(II) ions. However, the relationship was examined only in short-term zinc(II) treatments. Therefore, the aim of this study was to create zinc-resistant prostatic cell lines at various stages of the disease (22Rv1 and PC-3) and a normal prostate epithelium (PNT1A) using a long-term zinc exposure. Consequently, the expression profile of the following genes was analyzed: BAX, Bcl-2, Beclin-1, CFLAR, HIF1 alpha, KRAS, mTOR, MT1A, MT2A, NF-kappa B1, p53, survivin, ZIP1, ZnT-1. The resistance was verified using the MTT test; on average a 1.35-fold lower zinc(II) toxicity (higher IC50) was determined in zinc(II)-resistant cells. The associated resistance to cisplatin was also determined; IC50 for cisplatin was 1.52-fold higher. Zinc(II) ions are important components of many proteins and are involved in numerous cellular processes such as apoptosis or drug resistance. Prostate cancer has a unique relationship with zinc(II) ions. However, the relationship was examined only in short-term zinc(II) treatments. Therefore, the aim of this study was to create zinc-resistant prostatic cell lines at various stages of the disease (22Rv1 and PC-3) and a normal prostate epithelium (PNT1A) using a long-term zinc exposure. Consequently, the expression profile of the following genes was analyzed: BAX, Bcl-2, Beclin-1, CFLAR, HIF1 alpha, KRAS, mTOR, MT1A, MT2A, NF-kappa B1, p53, survivin, ZIP1, ZnT-1. The resistance was verified using the MTT test; on average a 1.35-fold lower zinc(II) toxicity (higher IC50) was determined in zinc(II)-resistant cells. The associated resistance to cisplatin was also determined; IC50 for cisplatin was 1.52-fold higher.
dcterms:title
KRAS NF-kappa B is involved in the development of zinc resistance and reduced curability in prostate cancer KRAS NF-kappa B is involved in the development of zinc resistance and reduced curability in prostate cancer
skos:prefLabel
KRAS NF-kappa B is involved in the development of zinc resistance and reduced curability in prostate cancer KRAS NF-kappa B is involved in the development of zinc resistance and reduced curability in prostate cancer
skos:notation
RIV/00216224:14110/14:00076568!RIV15-MSM-14110___
n3:aktivita
n15:V n15:S n15:O
n3:aktivity
O, S, V
n3:cisloPeriodika
7
n3:dodaniDat
n5:2015
n3:domaciTvurceVysledku
n6:1749072 n6:7381573 n6:5296692 n6:3931315 n6:4900219 n6:2222205
n3:druhVysledku
n17:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
25134
n3:idVysledku
RIV/00216224:14110/14:00076568
n3:jazykVysledku
n10:eng
n3:klicovaSlova
CITRATE METABOLISM; EPITHELIAL-CELLS; CARCINOMA-CELLS; DNA-DAMAGE; T-ANTIGEN; EXPRESSION; METALLOTHIONEIN; TRANSPORTER; APOPTOSIS; GENES
n3:klicoveSlovo
n4:CITRATE%20METABOLISM n4:GENES n4:EXPRESSION n4:TRANSPORTER n4:EPITHELIAL-CELLS n4:APOPTOSIS n4:CARCINOMA-CELLS n4:METALLOTHIONEIN n4:T-ANTIGEN n4:DNA-DAMAGE
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[612EC2AF0DAC]
n3:nazevZdroje
Metallomics
n3:obor
n7:CE
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n5:2014
n3:svazekPeriodika
6
n3:tvurceVysledku
Sztalmachová, Markéta Gumulec, Jaromír Holubová, Monika Adam, Vojtěch Axmanová, Martina Babula, Petr Masařík, Michal Raudenská, Martina Kizek, René
n3:wos
000338638000009
s:issn
1756-5901
s:numberOfPages
14
n9:doi
10.1039/c4mt00065j
n13:organizacniJednotka
14110