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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00075600%21RIV15-MSM-14110___
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Prostate cancer is the most prevalent cancer in males in developed countries. Tumor suppressor candidate 3 (TUSC3) has been identified as a putative tumor suppressor gene in prostate cancer, though its function has not been characterized. TUSC3 shares homologies with the yeast oligosaccharyltransferase (OST) complex subunit Ost3p, suggesting a role in protein glycosylation. We provide evidence that TUSC3 is part of the OST complex and affects N-linked glycosylation in mammalian cells. Loss of TUSC3 expression in DU145 and PC3 prostate cancer cell lines leads to increased proliferation, migration and invasion as well as accelerated xenograft growth in a PTEN negative background. TUSC3 downregulation also affects endoplasmic reticulum (ER) structure and stress response, which results in increased Akt signaling. Together, our findings provide first mechanistic insight in TUSC3 function in prostate carcinogenesis in general and N-glycosylation in particular. Prostate cancer is the most prevalent cancer in males in developed countries. Tumor suppressor candidate 3 (TUSC3) has been identified as a putative tumor suppressor gene in prostate cancer, though its function has not been characterized. TUSC3 shares homologies with the yeast oligosaccharyltransferase (OST) complex subunit Ost3p, suggesting a role in protein glycosylation. We provide evidence that TUSC3 is part of the OST complex and affects N-linked glycosylation in mammalian cells. Loss of TUSC3 expression in DU145 and PC3 prostate cancer cell lines leads to increased proliferation, migration and invasion as well as accelerated xenograft growth in a PTEN negative background. TUSC3 downregulation also affects endoplasmic reticulum (ER) structure and stress response, which results in increased Akt signaling. Together, our findings provide first mechanistic insight in TUSC3 function in prostate carcinogenesis in general and N-glycosylation in particular.
dcterms:title
TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo
skos:prefLabel
TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo
skos:notation
RIV/00216224:14110/14:00075600!RIV15-MSM-14110___
n4:aktivita
n15:P
n4:aktivity
P(7AMB12AT019)
n4:cisloPeriodika
%223739%22
n4:dodaniDat
n9:2015
n4:domaciTvurceVysledku
n10:6723381 n10:2729075
n4:druhVysledku
n16:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n19:predkladatel
n4:idSjednocenehoVysledku
51428
n4:idVysledku
RIV/00216224:14110/14:00075600
n4:jazykVysledku
n11:eng
n4:klicovaSlova
POSTTRANSLATIONAL N-GLYCOSYLATION; RECESSIVE MENTAL-RETARDATION; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; XBP1 MESSENGER-RNA; CHROMOSOME ARM 8P; OVARIAN-CANCER; OLIGOSACCHARYLTRANSFERASE; DELETION; GENE
n4:klicoveSlovo
n7:DELETION n7:RECESSIVE%20MENTAL-RETARDATION n7:OLIGOSACCHARYLTRANSFERASE n7:OVARIAN-CANCER n7:XBP1%20MESSENGER-RNA n7:POSTTRANSLATIONAL%20N-GLYCOSYLATION n7:UNFOLDED%20PROTEIN%20RESPONSE n7:CHROMOSOME%20ARM%208P n7:GENE n7:ENDOPLASMIC-RETICULUM%20STRESS
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[CD29850B0B6A]
n4:nazevZdroje
Scientific Reports
n4:obor
n13:FD
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
12
n4:projekt
n12:7AMB12AT019
n4:rokUplatneniVysledku
n9:2014
n4:svazekPeriodika
4
n4:tvurceVysledku
Vaňhara, Petr Horak, Peter Krainer, Michael Lemberger, Christof E. Sibilia, Maria Gerschpacher, Marion Anees, Mariam Tomasich, Erwin Marhold, Maximilian Pils, Dietmar Kratochvílová, Kateřina Horvat, Reinhard
n4:wos
000329849100005
s:issn
2045-2322
s:numberOfPages
9
n17:doi
10.1038/srep03739
n14:organizacniJednotka
14110