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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00075532%21RIV15-MSM-14110___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Hyperlipidemia is a well-accepted risk factor in the development of atherosclerosis. MicroRNAs (miRNAs), a novel class of posttranscriptional regulators of gene expression, are involved in a variety of biological and pathological processes, including the regulation of the lipid metabolism and atherosclerosis. As our knowledge of miRNAs expands, a new class of %22circulating miRNAs%22 has recently been described. It includes miRNAs which may be found in various bodily fluids packaged in microvesicles/exosomes, or bound to specific transporting proteins. High-density lipoprotein (HDL) particles have been identified as one such carrier. As this class of miRNAs likely plays a role in intercellular communication, it may also contribute to the atherosclerosis development and progression. This review aims to provide a comprehensive explanation of the roles of distinct miRNAs involved in the regulation of the lipid metabolism. Hyperlipidemia is a well-accepted risk factor in the development of atherosclerosis. MicroRNAs (miRNAs), a novel class of posttranscriptional regulators of gene expression, are involved in a variety of biological and pathological processes, including the regulation of the lipid metabolism and atherosclerosis. As our knowledge of miRNAs expands, a new class of %22circulating miRNAs%22 has recently been described. It includes miRNAs which may be found in various bodily fluids packaged in microvesicles/exosomes, or bound to specific transporting proteins. High-density lipoprotein (HDL) particles have been identified as one such carrier. As this class of miRNAs likely plays a role in intercellular communication, it may also contribute to the atherosclerosis development and progression. This review aims to provide a comprehensive explanation of the roles of distinct miRNAs involved in the regulation of the lipid metabolism.
dcterms:title
MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment
skos:prefLabel
MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment
skos:notation
RIV/00216224:14110/14:00075532!RIV15-MSM-14110___
n3:aktivita
n18:S n18:P
n3:aktivity
P(ED1.100/02/0123), S
n3:cisloPeriodika
275867
n3:dodaniDat
n10:2015
n3:domaciTvurceVysledku
n9:4447719 n9:4464850
n3:druhVysledku
n15:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
29210
n3:idVysledku
RIV/00216224:14110/14:00075532
n3:jazykVysledku
n12:eng
n3:klicovaSlova
microRNA; lipid metabolism; atherosclerosis; circulating microRNA
n3:klicoveSlovo
n4:circulating%20microRNA n4:atherosclerosis n4:microRNA n4:lipid%20metabolism
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[FDFC666152F4]
n3:nazevZdroje
Mediators of Inflammation
n3:obor
n6:ED
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n17:ED1.100%2F02%2F0123
n3:rokUplatneniVysledku
n10:2014
n3:svazekPeriodika
2014
n3:tvurceVysledku
Bienertová Vašků, Julie Novák, Miroslav Novák, Jan Kára, Tomáš
n3:wos
000335329700001
s:issn
0962-9351
s:numberOfPages
14
n19:doi
10.1155/2014/275867
n16:organizacniJednotka
14110