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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00075513%21RIV15-MSM-14110___
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Multiple myeloma still remains incurable in majority of cases prompting further search for new and better prognostic markers. Emerging evidence has suggested that circulating microRNAs can serve as minimally invasive biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance. In this study, a global analysis of serum microRNAs by TaqMan Low Density arrays was performed, followed by quantitative real-time PCR. The analyses revealed five deregulated microRNAs: miR-744, miR-130a, miR-34a, let-7d and let-7e in monoclonal gammopathy of undetermined significance, newly diagnosed and relapsed multiple myeloma when compared to healthy donors. Multivariate logistic regression analysis showed that combination of miR-34a and let-7e can distinguish multiple myeloma from healthy donors with sensitivity 80.6% and specificity 86.7% and monoclonal gammopathy of undetermined significance from healthy donors with sensitivity 91.1% and specificity 96.7%. Multiple myeloma still remains incurable in majority of cases prompting further search for new and better prognostic markers. Emerging evidence has suggested that circulating microRNAs can serve as minimally invasive biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance. In this study, a global analysis of serum microRNAs by TaqMan Low Density arrays was performed, followed by quantitative real-time PCR. The analyses revealed five deregulated microRNAs: miR-744, miR-130a, miR-34a, let-7d and let-7e in monoclonal gammopathy of undetermined significance, newly diagnosed and relapsed multiple myeloma when compared to healthy donors. Multivariate logistic regression analysis showed that combination of miR-34a and let-7e can distinguish multiple myeloma from healthy donors with sensitivity 80.6% and specificity 86.7% and monoclonal gammopathy of undetermined significance from healthy donors with sensitivity 91.1% and specificity 96.7%.
dcterms:title
Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance
skos:prefLabel
Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance
skos:notation
RIV/00216224:14110/14:00075513!RIV15-MSM-14110___
n3:aktivita
n4:I n4:P n4:Z
n3:aktivity
I, P(7E12070), P(NT13190), Z(MSM0021622434)
n3:cisloPeriodika
3
n3:dodaniDat
n13:2015
n3:domaciTvurceVysledku
n7:9478426 n7:9622748 n7:1447963 n7:7992157 n7:2294761 n7:9685596 n7:5132606 n7:1753142 n7:6933300 n7:3365891
n3:druhVysledku
n17:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
7322
n3:idVysledku
RIV/00216224:14110/14:00075513
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Multiple myeloma; MGUS; circulating miRNA; miRNA profiling; qPCR
n3:klicoveSlovo
n6:MGUS n6:Multiple%20myeloma n6:miRNA%20profiling n6:qPCR n6:circulating%20miRNA
n3:kodStatuVydavatele
IT - Italská republika
n3:kontrolniKodProRIV
[A403769118A8]
n3:nazevZdroje
Haematologica/the hematology journal
n3:obor
n16:FD
n3:pocetDomacichTvurcuVysledku
10
n3:pocetTvurcuVysledku
14
n3:projekt
n15:7E12070 n15:NT13190
n3:rokUplatneniVysledku
n13:2014
n3:svazekPeriodika
99
n3:tvurceVysledku
Jarkovský, Jiří Adam, Zdeněk Kuglík, Petr Kubiczková, Lenka Kryukov, Fedor Pour, Luděk Ševčíková, Sabina Slabý, Ondřej Nekvindová, Jana Grešliková, Henrieta Hájek, Roman Vetešníková, Eva Radová, Lenka Kryukova, Elena Vladimirovna
n3:wos
000336255000022
n3:zamer
n19:MSM0021622434
s:issn
0390-6078
s:numberOfPages
8
n20:doi
10.3324/haematol.2013.093500
n12:organizacniJednotka
14110