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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00075512%21RIV15-MSM-14110___
rdf:type
n16:Vysledek skos:Concept
dcterms:description
The current worldwide epidemic of metabolic syndrome represents an urgent challenge for new pharmacotherapy development. There is growing evidence of multiple metabolic dysregulations contributing to the development of the pathophysiological processes underlying metabolic syndrome. The adipose tissue metabolism and its endocrine activity is one of the key mechanisms believed to provide new targets for pharmacotherapy. The aim of this chapter is to provide a survey on metabolic syndrome pathophysiology, etiology and hypotheses of its development with special attention focused on insulin resistance, inflammatory processes and endocrine activity of the adipose tissue. Specific adipokines secreted by the body fat have multiple effects on the energy metabolism and can either support or suppress insulin signaling. Their pharmacological exploitation may lead to development of new treatments of insulin resistance and metabolic syndrome. The current worldwide epidemic of metabolic syndrome represents an urgent challenge for new pharmacotherapy development. There is growing evidence of multiple metabolic dysregulations contributing to the development of the pathophysiological processes underlying metabolic syndrome. The adipose tissue metabolism and its endocrine activity is one of the key mechanisms believed to provide new targets for pharmacotherapy. The aim of this chapter is to provide a survey on metabolic syndrome pathophysiology, etiology and hypotheses of its development with special attention focused on insulin resistance, inflammatory processes and endocrine activity of the adipose tissue. Specific adipokines secreted by the body fat have multiple effects on the energy metabolism and can either support or suppress insulin signaling. Their pharmacological exploitation may lead to development of new treatments of insulin resistance and metabolic syndrome.
dcterms:title
Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite
skos:prefLabel
Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite Adipose Tissue Endocrine Regulations in Metabolic Syndrome and Appetite
skos:notation
RIV/00216224:14110/14:00075512!RIV15-MSM-14110___
n3:aktivita
n19:I
n3:aktivity
I
n3:dodaniDat
n12:2015
n3:domaciTvurceVysledku
n8:2512866
n3:druhVysledku
n7:C
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
1651
n3:idVysledku
RIV/00216224:14110/14:00075512
n3:jazykVysledku
n9:eng
n3:klicovaSlova
metabolic syndrome; adipokines; leptin; adiponectin; resistin; AFABP
n3:klicoveSlovo
n10:resistin n10:AFABP n10:adipokines n10:adiponectin n10:metabolic%20syndrome n10:leptin
n3:kontrolniKodProRIV
[D2EFDCD45FB7]
n3:mistoVydani
New York
n3:nazevEdiceCisloSvazku
Human Anatomy and Physiology
n3:nazevZdroje
Appetite: Regulation, Use of Stimulants and Cultural and Biological Influences
n3:obor
n4:FR
n3:pocetDomacichTvurcuVysledku
1
n3:pocetStranKnihy
220
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n12:2014
n3:tvurceVysledku
Horská, Kateřina Kotolová, Hana Kučerová, Jana
s:numberOfPages
26
n13:hasPublisher
Nova Science Publishers
n5:isbn
9781631172434
n17:organizacniJednotka
14110