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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00075489%21RIV15-MSM-14110___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Epigenetic changes are generally based on the switching of alternative functional or structural states and result in the adaptation of cellular expression patterns during proliferation, differentiation or plastic changes in the adult organism, whereas some epigenetic information can be passed on other generations while other is not. Hence, the principal question is: why is some information reset or resolved during the meiosis process and other is passed from one generation to another, or, in other words: what %22adaptation trigger%22 level initiates transgenerationally transmitted epigenome change? Hereto, we propose a theory which states that stress, or, more specifically, the energy cost of an individual's adaptation to stress, represents a viable candidate for the transgenerational transmission trigger of a given acquired trait. Epigenetic changes are generally based on the switching of alternative functional or structural states and result in the adaptation of cellular expression patterns during proliferation, differentiation or plastic changes in the adult organism, whereas some epigenetic information can be passed on other generations while other is not. Hence, the principal question is: why is some information reset or resolved during the meiosis process and other is passed from one generation to another, or, in other words: what %22adaptation trigger%22 level initiates transgenerationally transmitted epigenome change? Hereto, we propose a theory which states that stress, or, more specifically, the energy cost of an individual's adaptation to stress, represents a viable candidate for the transgenerational transmission trigger of a given acquired trait.
dcterms:title
%22Stress entropic load%22 as a transgenerational epigenetic response trigger %22Stress entropic load%22 as a transgenerational epigenetic response trigger
skos:prefLabel
%22Stress entropic load%22 as a transgenerational epigenetic response trigger %22Stress entropic load%22 as a transgenerational epigenetic response trigger
skos:notation
RIV/00216224:14110/14:00075489!RIV15-MSM-14110___
n3:aktivita
n5:I n5:P n5:Z
n3:aktivity
I, P(ED2.1.00/03.0101), Z(MZ0MOU2005)
n3:cisloPeriodika
3
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n7:3620395 n7:4464850 n7:1990810 n7:2359812 n7:4447719
n3:druhVysledku
n4:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
47743
n3:idVysledku
RIV/00216224:14110/14:00075489
n3:jazykVysledku
n13:eng
n3:klicovaSlova
ALLOSTASIS; PLASTICITY
n3:klicoveSlovo
n8:PLASTICITY n8:ALLOSTASIS
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[647E7B266855]
n3:nazevZdroje
Medical Hypotheses
n3:obor
n18:ED
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n10:ED2.1.00%2F03.0101
n3:rokUplatneniVysledku
n9:2014
n3:svazekPeriodika
82
n3:tvurceVysledku
Nečesánek, Ivo Bienertová-Vašků, Julie Zlámal, Filip Vinklárek, Jan Novák, Jan
n3:wos
000333494100006
n3:zamer
n19:MZ0MOU2005
s:issn
0306-9877
s:numberOfPages
4
n17:doi
10.1016/j.mehy.2013.12.008
n6:organizacniJednotka
14110