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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00075026%21RIV15-MSM-14110___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Introduction: In schizophrenia, disruption of the neurodevelopmental processes may lead to brain changes and subsequent clinical manifestations of the illness. Reports of the progressive nature of these morphological brain changes raise questions about their causes. The possible toxic effects of repeated stressful psychotic episodes may contribute to the disease progression. Objectives: To analyze the influence of illness duration and previous psychotic episodes on hippocampal gray matter volume (GMV) in schizophrenia. Methods: We performed an analysis of hippocampal GMV correlations with illness duration, number of previous psychotic episodes, and age in 24 schizophrenia patients and 24 matched healthy controls. Results: We found a cluster of GMV voxels in the left hippocampal tail that negatively correlated with the number of previous psychotic episodes, independent from the effect of age. On the other hand we found no effect of illness duration independent of age on the hippocampal GMV. Introduction: In schizophrenia, disruption of the neurodevelopmental processes may lead to brain changes and subsequent clinical manifestations of the illness. Reports of the progressive nature of these morphological brain changes raise questions about their causes. The possible toxic effects of repeated stressful psychotic episodes may contribute to the disease progression. Objectives: To analyze the influence of illness duration and previous psychotic episodes on hippocampal gray matter volume (GMV) in schizophrenia. Methods: We performed an analysis of hippocampal GMV correlations with illness duration, number of previous psychotic episodes, and age in 24 schizophrenia patients and 24 matched healthy controls. Results: We found a cluster of GMV voxels in the left hippocampal tail that negatively correlated with the number of previous psychotic episodes, independent from the effect of age. On the other hand we found no effect of illness duration independent of age on the hippocampal GMV.
dcterms:title
Psychosis effect on hippocampal reduction in schizophrenia Psychosis effect on hippocampal reduction in schizophrenia
skos:prefLabel
Psychosis effect on hippocampal reduction in schizophrenia Psychosis effect on hippocampal reduction in schizophrenia
skos:notation
RIV/00216224:14110/14:00075026!RIV15-MSM-14110___
n3:aktivita
n18:I
n3:aktivity
I
n3:cisloPeriodika
3 Jan 2014
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n8:9175474 n8:8207852 n8:5052068 n8:3436292
n3:druhVysledku
n15:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
40830
n3:idVysledku
RIV/00216224:14110/14:00075026
n3:jazykVysledku
n5:eng
n3:klicovaSlova
hippocampus; morphometry; psychosis; schizophrenia; toxicity
n3:klicoveSlovo
n9:morphometry n9:psychosis n9:hippocampus n9:schizophrenia n9:toxicity
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[01C40DFDB16D]
n3:nazevZdroje
Progress in Neuro-Psychopharmacology and Biological Psychiatry
n3:obor
n10:FL
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n7:2014
n3:svazekPeriodika
48
n3:tvurceVysledku
Hýža, Martin Hüttlová, Jitka Kašpárek, Tomáš Keřkovský, Miloš
n3:wos
000328074200027
s:issn
0278-5846
s:numberOfPages
7
n14:doi
10.1016/j.pnpbp.2013.10.008
n17:organizacniJednotka
14110