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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00073562%21RIV15-MSM-14110___
rdf:type
n5:Vysledek skos:Concept
dcterms:description
The stem cell marker nestin (NES) is found in dividing cells of developing and regenerating tissues. Upon terminal differentiation, NES expression is diminished but may be re-expressed following injury or in cancer. Surprisingly, we recently confirmed NES as a tumour-specific marker for mature CD138(+)38(+) plasma cells (PC) in multiple myeloma (MM). The present study analysed NES expression throughout the spectrum of MM developmental stages, starting with individuals with no haematological malignancy, through monoclonal gammopathy of undetermined significance (MGUS) and MM to plasma cell leukaemia (PCL) and MM cell lines. NES was analysed in bone marrow PC of 163 MM, four PCL and nine MGUS patients, 10 individuals with no haematological malignancy and 6 myeloma cell lines (OPM-2, RPMI-8226, MOLP-8, U-266, EJM, NCI-H929) by flow cytometry and/or real-time polymerase chain reaction or immunochemistry. We observed a tendency of increased NES expression in parallel with disease progression. The stem cell marker nestin (NES) is found in dividing cells of developing and regenerating tissues. Upon terminal differentiation, NES expression is diminished but may be re-expressed following injury or in cancer. Surprisingly, we recently confirmed NES as a tumour-specific marker for mature CD138(+)38(+) plasma cells (PC) in multiple myeloma (MM). The present study analysed NES expression throughout the spectrum of MM developmental stages, starting with individuals with no haematological malignancy, through monoclonal gammopathy of undetermined significance (MGUS) and MM to plasma cell leukaemia (PCL) and MM cell lines. NES was analysed in bone marrow PC of 163 MM, four PCL and nine MGUS patients, 10 individuals with no haematological malignancy and 6 myeloma cell lines (OPM-2, RPMI-8226, MOLP-8, U-266, EJM, NCI-H929) by flow cytometry and/or real-time polymerase chain reaction or immunochemistry. We observed a tendency of increased NES expression in parallel with disease progression.
dcterms:title
Nestin expression throughout multistep pathogenesis of multiple myeloma Nestin expression throughout multistep pathogenesis of multiple myeloma
skos:prefLabel
Nestin expression throughout multistep pathogenesis of multiple myeloma Nestin expression throughout multistep pathogenesis of multiple myeloma
skos:notation
RIV/00216224:14110/14:00073562!RIV15-MSM-14110___
n3:aktivita
n8:Z n8:P n8:I
n3:aktivity
I, P(GAP304/10/1395), P(NT11154), P(NT13190), Z(MSM0021622434)
n3:cisloPeriodika
5
n3:dodaniDat
n6:2015
n3:domaciTvurceVysledku
n4:4954130 n4:2294761 n4:6012329 n4:1753142 n4:1294172 n4:5132606 n4:3365891 n4:9622748
n3:druhVysledku
n12:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
32185
n3:idVysledku
RIV/00216224:14110/14:00073562
n3:jazykVysledku
n15:eng
n3:klicovaSlova
nestin; multiple myeloma; monoclonal gammopathy; stem cells; flow cytometry
n3:klicoveSlovo
n13:stem%20cells n13:nestin n13:multiple%20myeloma n13:flow%20cytometry n13:monoclonal%20gammopathy
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[B14C7CDD60CC]
n3:nazevZdroje
British journal of haematology
n3:obor
n18:FD
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
9
n3:projekt
n11:NT11154 n11:NT13190 n11:GAP304%2F10%2F1395
n3:rokUplatneniVysledku
n6:2014
n3:svazekPeriodika
164
n3:tvurceVysledku
Kryukov, Fedor Říhová, Lucie Grešliková, Henrieta Ševčíková, Sabina Kryukova, Elena Vladimirovna Kubiczková, Lenka Hájek, Roman Šváchová, Hana Němec, Pavel
n3:wos
000331354700011
n3:zamer
n19:MSM0021622434
s:issn
0007-1048
s:numberOfPages
9
n17:doi
10.1111/bjh.12689
n20:organizacniJednotka
14110