This HTML5 document contains 66 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n16http://localhost/temp/predkladatel/
n11http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n20http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216224%3A14110%2F14%3A00073433%21RIV15-MSM-14110___/
n9http://linked.opendata.cz/resource/domain/vavai/projekt/
n18http://linked.opendata.cz/ontology/domain/vavai/
n8http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/
skoshttp://www.w3.org/2004/02/skos/core#
n19http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n7http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n14http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n13http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n6http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n12http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00073433%21RIV15-MSM-14110___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Multiple myeloma (MM) is an incurable malignant disease of the terminal developmental stage of B-lymphocytes. While genetic heterogeneity of MM is widely described, little is known about its genetic basis as well as primary damage during plasma cells (PC) development. In this study, we focused on genome-wide screening of DNA copy number changes using oligonucleotide-based array-CGH together with I-FISH of the IgH locus rearrangements in pair samples of bone marrow B-cells (CD19+) and CD138+ PC from newly diagnosed MM patients. The IgH disruption was found in 8.9% (4/45) of CD19+ samples and in 57.8% (26/45) of CD138+ samples. The genomic profiling using array-CGH identified copy number alterations (CNAs) in 10% (2/20) of CD19+ samples in regions known to be important for MM pathogenesis. In contrast, we found CNAs in 100% (16/16) of CD138+ samples. Multiple myeloma (MM) is an incurable malignant disease of the terminal developmental stage of B-lymphocytes. While genetic heterogeneity of MM is widely described, little is known about its genetic basis as well as primary damage during plasma cells (PC) development. In this study, we focused on genome-wide screening of DNA copy number changes using oligonucleotide-based array-CGH together with I-FISH of the IgH locus rearrangements in pair samples of bone marrow B-cells (CD19+) and CD138+ PC from newly diagnosed MM patients. The IgH disruption was found in 8.9% (4/45) of CD19+ samples and in 57.8% (26/45) of CD138+ samples. The genomic profiling using array-CGH identified copy number alterations (CNAs) in 10% (2/20) of CD19+ samples in regions known to be important for MM pathogenesis. In contrast, we found CNAs in 100% (16/16) of CD138+ samples.
dcterms:title
Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH
skos:prefLabel
Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH
skos:notation
RIV/00216224:14110/14:00073433!RIV15-MSM-14110___
n4:aktivita
n13:Z n13:P
n4:aktivity
P(GAP304/10/1395), P(NS10207), P(NT11154), P(NT13190), P(NT13492), Z(MSM0021622434)
n4:cisloPeriodika
1
n4:dodaniDat
n12:2015
n4:domaciTvurceVysledku
n11:7992157 n11:3440095 n11:5598028 n11:6012329 n11:1756958 n11:2294761 n11:1753142 n11:8894272 n11:9622748 n11:6933300
n4:druhVysledku
n17:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n20:predkladatel
n4:idSjednocenehoVysledku
21116
n4:idVysledku
RIV/00216224:14110/14:00073433
n4:jazykVysledku
n6:eng
n4:klicovaSlova
multiple myeloma; CD19+; CD138+; cytogenetics; array-CGH; FISH
n4:klicoveSlovo
n7:array-CGH n7:multiple%20myeloma n7:CD19%2B n7:cytogenetics n7:FISH n7:CD138%2B
n4:kodStatuVydavatele
SK - Slovenská republika
n4:kontrolniKodProRIV
[B71A4E0B141E]
n4:nazevZdroje
Neoplasma
n4:obor
n15:FD
n4:pocetDomacichTvurcuVysledku
10
n4:pocetTvurcuVysledku
10
n4:projekt
n9:NT13492 n9:NT11154 n9:NS10207 n9:GAP304%2F10%2F1395 n9:NT13190
n4:rokUplatneniVysledku
n12:2014
n4:svazekPeriodika
61
n4:tvurceVysledku
Kryukova, Elena Vladimirovna Grešliková, Henrieta Kryukov, Fedor Němec, Pavel Kupská, Renata Kuglík, Petr Ihnatová, Ivana Smetana, Jan Mikulášová, Aneta Hájek, Roman
n4:wos
000329769500007
n4:zamer
n8:MSM0021622434
s:issn
0028-2685
s:numberOfPages
8
n19:doi
10.4149/neo_2014_008
n16:organizacniJednotka
14110