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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F14%3A00073417%21RIV15-MSM-14110___
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Background: Multiple myeloma (MM) is a malignancy of plasma cells frequently associated with immune abnormalities. Several studies have confirmed that in MM immune deregulation can be mediated by increased numbers of CD4 T regulatory (Treg) cells, and these cells were also associated with poor outcome. In this study, we aimed to study CD8 Treg cells before and after lenalidomide plus dexamethasone (len-dex) treatment in MM patients. Methods: Using flow cytometry, we enumerated and assessed suppressive function of CD8 Treg cells in 16 MM patients before and after len-dex treatment. Results: Numbers of CD8 Treg cells (CD8+CD25hi+FoxP3+) (P < 0.01) were significantly increased in MM patients (before treatment) compared to healthy donors. However, no significant changes were observed in CD4 and CD8 T cells. A significant increase in CD8 Treg cells was observed after len-dex treatment compared to pre-treatment but no significant difference was observed in CD4 and CD8 T cells. Background: Multiple myeloma (MM) is a malignancy of plasma cells frequently associated with immune abnormalities. Several studies have confirmed that in MM immune deregulation can be mediated by increased numbers of CD4 T regulatory (Treg) cells, and these cells were also associated with poor outcome. In this study, we aimed to study CD8 Treg cells before and after lenalidomide plus dexamethasone (len-dex) treatment in MM patients. Methods: Using flow cytometry, we enumerated and assessed suppressive function of CD8 Treg cells in 16 MM patients before and after len-dex treatment. Results: Numbers of CD8 Treg cells (CD8+CD25hi+FoxP3+) (P < 0.01) were significantly increased in MM patients (before treatment) compared to healthy donors. However, no significant changes were observed in CD4 and CD8 T cells. A significant increase in CD8 Treg cells was observed after len-dex treatment compared to pre-treatment but no significant difference was observed in CD4 and CD8 T cells.
dcterms:title
Flow Cytometry-Based Enumeration and Functional Characterization of CD8 T Regulatory Cells in Patients with Multiple Myeloma Before and After Lenalidomide Plus Dexamethasone Treatment Flow Cytometry-Based Enumeration and Functional Characterization of CD8 T Regulatory Cells in Patients with Multiple Myeloma Before and After Lenalidomide Plus Dexamethasone Treatment
skos:prefLabel
Flow Cytometry-Based Enumeration and Functional Characterization of CD8 T Regulatory Cells in Patients with Multiple Myeloma Before and After Lenalidomide Plus Dexamethasone Treatment Flow Cytometry-Based Enumeration and Functional Characterization of CD8 T Regulatory Cells in Patients with Multiple Myeloma Before and After Lenalidomide Plus Dexamethasone Treatment
skos:notation
RIV/00216224:14110/14:00073417!RIV15-MSM-14110___
n3:aktivita
n9:P n9:Z
n3:aktivity
P(GAP304/10/1395), Z(MSM0021622434)
n3:cisloPeriodika
4
n3:dodaniDat
n17:2015
n3:domaciTvurceVysledku
n7:3042642 n7:4954130 n7:9622748
n3:druhVysledku
n8:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
17053
n3:idVysledku
RIV/00216224:14110/14:00073417
n3:jazykVysledku
n19:eng
n3:klicovaSlova
CD8 T regulatory cells; multiple myeloma; immune suppression; lenalidomide; dexamethasone; flow cytometry and CFSE
n3:klicoveSlovo
n4:lenalidomide n4:CD8%20T%20regulatory%20cells n4:multiple%20myeloma n4:dexamethasone n4:flow%20cytometry%20and%20CFSE n4:immune%20suppression
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[CB48A1BA26E5]
n3:nazevZdroje
Cytometry Part B ( Clinical cytometry)
n3:obor
n12:FD
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
6
n3:projekt
n20:GAP304%2F10%2F1395
n3:rokUplatneniVysledku
n17:2014
n3:svazekPeriodika
86
n3:tvurceVysledku
Říhová, Lucie Pelcová, Jana Muthu Raja, Karthick Raja Hájek, Roman Adam, Zdeněk Plášil, Martin
n3:wos
000340544300001
n3:zamer
n18:MSM0021622434
s:issn
1552-4949
s:numberOfPages
9
n11:doi
10.1002/cyto.b.21109
n15:organizacniJednotka
14110