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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F13%3A00071767%21RIV14-MSM-14110___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Dendritic cells (DCs) are the most potent professional antigen-presenting cells, capable of initiating proper adaptive immune responses. Although tumor-infiltrating DCs are able to recognize cancer cells and uptake tumor antigens, they often have impaired functions because of the immunosuppressive tumor milieu. Therefore, DCs are targeted by therapeutic means either in vivo or ex vivo to facilitate tumor antigen presentation to T cells and induce or promote efficient antitumor immune responses in cancer patients. This immunotherapeutical approach is defined as specific active tumor immunotherapy or therapeutic cancer vaccination. In this review we briefly discuss general aspects of DC biology, followed by a thorough description of the current knowledge and optimization trends of DC vaccine production ex vivo, including various approaches for the induction of proper DC maturation and efficient loading with tumor antigens. Dendritic cells (DCs) are the most potent professional antigen-presenting cells, capable of initiating proper adaptive immune responses. Although tumor-infiltrating DCs are able to recognize cancer cells and uptake tumor antigens, they often have impaired functions because of the immunosuppressive tumor milieu. Therefore, DCs are targeted by therapeutic means either in vivo or ex vivo to facilitate tumor antigen presentation to T cells and induce or promote efficient antitumor immune responses in cancer patients. This immunotherapeutical approach is defined as specific active tumor immunotherapy or therapeutic cancer vaccination. In this review we briefly discuss general aspects of DC biology, followed by a thorough description of the current knowledge and optimization trends of DC vaccine production ex vivo, including various approaches for the induction of proper DC maturation and efficient loading with tumor antigens.
dcterms:title
Therapeutic Dendritic Cell-Based Cancer Vaccines: The State of the Art Therapeutic Dendritic Cell-Based Cancer Vaccines: The State of the Art
skos:prefLabel
Therapeutic Dendritic Cell-Based Cancer Vaccines: The State of the Art Therapeutic Dendritic Cell-Based Cancer Vaccines: The State of the Art
skos:notation
RIV/00216224:14110/13:00071767!RIV14-MSM-14110___
n7:predkladatel
n14:orjk%3A14110
n3:aktivita
n19:P
n3:aktivity
P(EE2.3.20.0012), P(LM2011017)
n3:cisloPeriodika
6
n3:dodaniDat
n5:2014
n3:domaciTvurceVysledku
n8:4298543 n8:6522319
n3:druhVysledku
n20:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
110855
n3:idVysledku
RIV/00216224:14110/13:00071767
n3:jazykVysledku
n16:eng
n3:klicovaSlova
dendritic cells; therapeutic cancer vaccines; maturation cocktails; polarizing signal; homing signal
n3:klicoveSlovo
n11:polarizing%20signal n11:dendritic%20cells n11:homing%20signal n11:therapeutic%20cancer%20vaccines n11:maturation%20cocktails
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[6C619630609E]
n3:nazevZdroje
CRITICAL REVIEWS IN IMMUNOLOGY
n3:obor
n15:EC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
8
n3:projekt
n17:EE2.3.20.0012 n17:LM2011017
n3:rokUplatneniVysledku
n5:2013
n3:svazekPeriodika
33
n3:tvurceVysledku
Ostapenko, Valerijus Michálek, Jaroslav Matúšková, Miroslava Powell, Daniel J. Jr. Schijns, Virgil Strioga, Marius Felzmann, Thomas Dobrovolskiene, Neringa T.
n3:wos
000326204600002
s:issn
1040-8401
s:numberOfPages
59
n18:doi
10.1615/CritRevImmunol.2013008033
n13:organizacniJednotka
14110