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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F13%3A00069848%21RIV14-MSM-14110___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
A lot of attention is paid to vitamin D in the last few years due to its broader spectrum of influence in human organs. Nuclear vitamin D receptors (VDR) are proved to be a main mechanism of action. More and more evidence of the negative influence of vitamin D deficiency on cardiovascular system appears together with low vitamin D serum levels in the current population, mostly due to life style with little exposure of unprotected skin to sun light. The course of ischemic heart disease can be worsened by low serum level of vitamin D because of higher risk of myocardial infarction a cardiac failure with more frequent hospitalisations. Higher risk of arrythmias during vitamin D deficiency is explained by higher production of parathormone and its binding to receptors stimulating phospholipase C followed by increased activity of catecholamines, angiotensin II and endothelin in ischaemic myocardium. A lot of attention is paid to vitamin D in the last few years due to its broader spectrum of influence in human organs. Nuclear vitamin D receptors (VDR) are proved to be a main mechanism of action. More and more evidence of the negative influence of vitamin D deficiency on cardiovascular system appears together with low vitamin D serum levels in the current population, mostly due to life style with little exposure of unprotected skin to sun light. The course of ischemic heart disease can be worsened by low serum level of vitamin D because of higher risk of myocardial infarction a cardiac failure with more frequent hospitalisations. Higher risk of arrythmias during vitamin D deficiency is explained by higher production of parathormone and its binding to receptors stimulating phospholipase C followed by increased activity of catecholamines, angiotensin II and endothelin in ischaemic myocardium.
dcterms:title
Vitamin D and cardiovascular diseases Vitamin D and cardiovascular diseases
skos:prefLabel
Vitamin D and cardiovascular diseases Vitamin D and cardiovascular diseases
skos:notation
RIV/00216224:14110/13:00069848!RIV14-MSM-14110___
n14:predkladatel
n16:orjk%3A14110
n3:aktivita
n13:I
n3:aktivity
I
n3:cisloPeriodika
3
n3:dodaniDat
n12:2014
n3:domaciTvurceVysledku
n6:4484630 n6:3160394 n6:9026592 n6:5584159 n6:3959937
n3:druhVysledku
n8:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
114231
n3:idVysledku
RIV/00216224:14110/13:00069848
n3:jazykVysledku
n9:eng
n3:klicovaSlova
vitamin D; vitamin D receptor; hypertension; ischemic heart disease; cardiac failure
n3:klicoveSlovo
n7:cardiac%20failure n7:vitamin%20D n7:ischemic%20heart%20disease n7:hypertension n7:vitamin%20D%20receptor
n3:kodStatuVydavatele
FR - Francouzská republika
n3:kontrolniKodProRIV
[C1449597111A]
n3:nazevZdroje
Journal of Aging Research & Clinical Practice
n3:obor
n5:FP
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n12:2013
n3:svazekPeriodika
2
n3:tvurceVysledku
Matejovsky, J. Weber, Pavel Fernandová, Emmanuela Meluzínová, Hana Matějovská Kubešová, Hana Bielaková, Katarína Polcarová, Vlasta
s:issn
2258-8094
s:numberOfPages
5
n17:organizacniJednotka
14110