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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F13%3A00069034%21RIV14-MSM-14110___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers. With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers.
dcterms:title
Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
skos:prefLabel
Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
skos:notation
RIV/00216224:14110/13:00069034!RIV14-MSM-14110___
n12:predkladatel
n19:orjk%3A14110
n3:aktivita
n8:I n8:P
n3:aktivity
I, P(ED2.1.00/03.0101)
n3:cisloPeriodika
42
n3:dodaniDat
n11:2014
n3:domaciTvurceVysledku
n4:6595596 n4:6229182 n4:9267360 n4:3503216 n4:5270340
n3:druhVysledku
n7:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
103353
n3:idVysledku
RIV/00216224:14110/13:00069034
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Platelet; PF-4; CTAP-III; Cancer; Angiogenesis; IL-8; Inflammation
n3:klicoveSlovo
n6:Angiogenesis n6:Cancer n6:Platelet n6:CTAP-III n6:Inflammation n6:IL-8 n6:PF-4
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[378FBF08596E]
n3:nazevZdroje
Journal of Hematology & Oncology
n3:obor
n14:FD
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:projekt
n10:ED2.1.00%2F03.0101
n3:rokUplatneniVysledku
n11:2013
n3:svazekPeriodika
6
n3:tvurceVysledku
Pilátová, Kateřina Bencsiková, Beatrix Zdražilová Dubská, Lenka Klement, Giannoula Lakka Greplová, Kristína Demlová, Regina
n3:wos
000321009900001
s:issn
1756-8722
s:numberOfPages
8
n15:doi
10.1186/1756-8722-6-42
n18:organizacniJednotka
14110