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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F13%3A00068281%21RIV14-MSM-14110___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Splenectomy has been used in patients with common variable immunodeficiency disorders (CVID), mainly in the context of refractory autoimmune cytopenia and suspected lymphoma, but there are understandable concerns about the potential of compounding an existing immunodeficiency. With increasing use of rituximab as an alternative treatment for refractory autoimmune cytopenia, the role of splenectomy in CVID needs to be re-examined. This retrospective study provides the largest cohesive data set to date describing the outcome of splenectomy in 45 CVID patients in the past 40 years. Splenectomy proved to be an effective long-term treatment in 75% of CVID patients with autoimmune cytopenia, even in some cases when rituximab had failed. Splenectomy does not worsen mortality in CVID and adequate immunoglobulin replacement therapy appears to play a protective role in overwhelming post-splenectomy infections. Splenectomy has been used in patients with common variable immunodeficiency disorders (CVID), mainly in the context of refractory autoimmune cytopenia and suspected lymphoma, but there are understandable concerns about the potential of compounding an existing immunodeficiency. With increasing use of rituximab as an alternative treatment for refractory autoimmune cytopenia, the role of splenectomy in CVID needs to be re-examined. This retrospective study provides the largest cohesive data set to date describing the outcome of splenectomy in 45 CVID patients in the past 40 years. Splenectomy proved to be an effective long-term treatment in 75% of CVID patients with autoimmune cytopenia, even in some cases when rituximab had failed. Splenectomy does not worsen mortality in CVID and adequate immunoglobulin replacement therapy appears to play a protective role in overwhelming post-splenectomy infections.
dcterms:title
Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients
skos:prefLabel
Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients
skos:notation
RIV/00216224:14110/13:00068281!RIV14-MSM-14110___
n13:predkladatel
n14:orjk%3A14110
n3:aktivita
n5:P
n3:aktivity
P(7E08062)
n3:cisloPeriodika
1
n3:dodaniDat
n17:2014
n3:domaciTvurceVysledku
n10:9731490
n3:druhVysledku
n7:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
94893
n3:idVysledku
RIV/00216224:14110/13:00068281
n3:jazykVysledku
n11:eng
n3:klicovaSlova
autoimmune cytopenia; common variable immunodeficiency; splenectomy; splenomegaly
n3:klicoveSlovo
n6:splenomegaly n6:splenectomy n6:autoimmune%20cytopenia n6:common%20variable%20immunodeficiency
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[E6044CBA2B75]
n3:nazevZdroje
Clinical and Experimental Immunology
n3:obor
n15:EC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
30
n3:projekt
n4:7E08062
n3:rokUplatneniVysledku
n17:2013
n3:svazekPeriodika
172
n3:tvurceVysledku
Hammarstrom, L. Winterhalter, C. Warnatz, K. Carbone, J. Kutukculer, N. Ernst, D. Fernandez-Cruz, E. Baumann, U. Chapel, H. Gonzalez-Granado, L. I. Ibrahim, M. A. A. Martini, H. Alecsandru, D. Grimbacher, B. Wong, G. K. Huissoon, A. P. Plebani, A. Lougaris, V. Contreras, R. McEwen, D. Gaspar, H. B. Vidaller, A. Schmidt, R. E. Kiani-Alikhan, S. Espanol, T. Litzman, Jiří Jones, A. Goldacker, S. Quinti, I. Lucas, M.
n3:wos
000316212200008
s:issn
0009-9104
s:numberOfPages
10
n20:doi
10.1111/cei.12039
n16:organizacniJednotka
14110