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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F13%3A00068061%21RIV14-MSM-14110___
rdf:type
n20:Vysledek skos:Concept
dcterms:description
The induction of senescence in cancer cells is believed to be a potent mechanism of tumor suppression; however, senescent cells remain metabolically active and secrete a broad spectrum of factors, modulate the tissue microenvironment, and potentially promote tumorigenicity in neighboring malignant cells. Another important subpopulation of secretory cells modulating the prostate tissue microenvironment is represented by neuroendocrine cells. Interestingly, androgen deprivation therapy, a widely used treatment for advanced prostate cancer, induces both the emergence of neuroendocrine-like prostate cancer cells and the senescence-associated secretory phenotype in prostate cancer epithelial cells. The induction of senescence in cancer cells is believed to be a potent mechanism of tumor suppression; however, senescent cells remain metabolically active and secrete a broad spectrum of factors, modulate the tissue microenvironment, and potentially promote tumorigenicity in neighboring malignant cells. Another important subpopulation of secretory cells modulating the prostate tissue microenvironment is represented by neuroendocrine cells. Interestingly, androgen deprivation therapy, a widely used treatment for advanced prostate cancer, induces both the emergence of neuroendocrine-like prostate cancer cells and the senescence-associated secretory phenotype in prostate cancer epithelial cells.
dcterms:title
Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation
skos:prefLabel
Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation
skos:notation
RIV/00216224:14110/13:00068061!RIV14-MSM-14110___
n20:predkladatel
n23:orjk%3A14110
n3:aktivita
n13:P n13:Z
n3:aktivity
P(ED1.100/02/0123), Z(MSM0021622430)
n3:dodaniDat
n17:2014
n3:domaciTvurceVysledku
n19:6723381 n19:9484892
n3:druhVysledku
n4:C
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
75526
n3:idVysledku
RIV/00216224:14110/13:00068061
n3:jazykVysledku
n8:eng
n3:klicovaSlova
prostate cancer; senescence; neuroendocrine differentiation; senescence-associated secretory phenotype; androgen receptor; Skp2
n3:klicoveSlovo
n10:Skp2 n10:senescence-associated%20secretory%20phenotype n10:androgen%20receptor n10:prostate%20cancer n10:senescence n10:neuroendocrine%20differentiation
n3:kontrolniKodProRIV
[3B1FC98AEB36]
n3:mistoVydani
Dordrecht
n3:nazevEdiceCisloSvazku
Aging, Cancer, and Noncancer Pathologies, Vol. 1
n3:nazevZdroje
Tumor Dormancy, Quiescence and Senescence
n3:obor
n7:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetStranKnihy
324
n3:pocetTvurcuVysledku
3
n3:projekt
n12:ED1.100%2F02%2F0123
n3:rokUplatneniVysledku
n17:2013
n3:tvurceVysledku
Pernicová, Zuzana Souček, Karel Vaňhara, Petr
n3:zamer
n18:MSM0021622430
s:numberOfPages
14
n21:doi
10.1007/978-94-007-5958-9_26
n11:hasPublisher
Springer Science+Business Media
n9:isbn
9789400759572
n22:organizacniJednotka
14110