This HTML5 document contains 45 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n10http://localhost/temp/predkladatel/
n13http://linked.opendata.cz/resource/domain/vavai/projekt/
n9http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n8http://linked.opendata.cz/resource/domain/vavai/subjekt/
n7http://linked.opendata.cz/ontology/domain/vavai/
n19http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216224%3A14110%2F13%3A00067733%21RIV14-MSM-14110___/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n11http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n6http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n20http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n18http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n14http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F13%3A00067733%21RIV14-MSM-14110___
rdf:type
skos:Concept n7:Vysledek
dcterms:description
Tumor growth and cancer development are considered clear examples of Darwinian selection, whereby random mutational events in heterogeneous cancer cell populations that best fit the selective microenvironment are preferred.1 As a result, cancer cells evolve resistance to apoptosis, hide from immune surveillance and acquire the ability to invade other organs. Cancer cells, however, are not necessarily passive subjects of selection; they can actively subvert the host tissue to provide a favorable habitat for their growth. Recent findings by Calon et al. convincingly demonstrate that transforming growth factor-b-induced secretion of interleukin 11 by tumor stromal fibroblasts is a necessary prerequisite for the development of distant metastases in colorectal carcinoma. Thus, understanding the complex molecular feedback loops between cancer cells and the surrounding microenvironment (i.e. Tumor growth and cancer development are considered clear examples of Darwinian selection, whereby random mutational events in heterogeneous cancer cell populations that best fit the selective microenvironment are preferred.1 As a result, cancer cells evolve resistance to apoptosis, hide from immune surveillance and acquire the ability to invade other organs. Cancer cells, however, are not necessarily passive subjects of selection; they can actively subvert the host tissue to provide a favorable habitat for their growth. Recent findings by Calon et al. convincingly demonstrate that transforming growth factor-b-induced secretion of interleukin 11 by tumor stromal fibroblasts is a necessary prerequisite for the development of distant metastases in colorectal carcinoma. Thus, understanding the complex molecular feedback loops between cancer cells and the surrounding microenvironment (i.e.
dcterms:title
Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases
skos:prefLabel
Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases
skos:notation
RIV/00216224:14110/13:00067733!RIV14-MSM-14110___
n7:predkladatel
n8:orjk%3A14110
n3:aktivita
n18:P
n3:aktivity
P(7AMB12AT019), P(ED1.100/02/0123)
n3:cisloPeriodika
2
n3:dodaniDat
n14:2014
n3:domaciTvurceVysledku
n9:6723381
n3:druhVysledku
n17:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
90247
n3:idVysledku
RIV/00216224:14110/13:00067733
n3:jazykVysledku
n20:eng
n3:klicovaSlova
metastasis; transforming growth factor-b; interleukin 11; metastatic niche; tumor stroma; dissemination; microenvironment
n3:klicoveSlovo
n6:interleukin%2011 n6:metastasis n6:transforming%20growth%20factor-b n6:microenvironment n6:tumor%20stroma n6:metastatic%20niche n6:dissemination
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[1FBD70BE44FE]
n3:nazevZdroje
JAK-STAT
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:projekt
n13:ED1.100%2F02%2F0123 n13:7AMB12AT019
n3:rokUplatneniVysledku
n14:2013
n3:svazekPeriodika
2
n3:tvurceVysledku
Souček, Karel Vaňhara, Petr
s:issn
2162-3996
s:numberOfPages
4
n11:doi
10.4161/jkst.23810
n10:organizacniJednotka
14110