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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F13%3A00067476%21RIV14-MSM-14110___
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Acquired mutations in the IDH1 and IDH2 genes have been detected in various hematological disorders, including acute myeloid leukemia (AML), where the incidence has been reported to be 15%. The IDH1 and IDH2 genes encode enzymes that catalyze oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG). Somatic mutations cause their dysfunction and an accumulation of aberrant 2-hydroxygluterate (2-HG) product in cells. The decreased supply of alpha-KG or increased accumulation of 2-HG (i.e. metabolic biomarker of mutant IDH1/2 enzyme activity) is considered to be a possible basis for the oncogenic properties of IDH mutants. Acquired mutations in the IDH1 and IDH2 genes have been detected in various hematological disorders, including acute myeloid leukemia (AML), where the incidence has been reported to be 15%. The IDH1 and IDH2 genes encode enzymes that catalyze oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG). Somatic mutations cause their dysfunction and an accumulation of aberrant 2-hydroxygluterate (2-HG) product in cells. The decreased supply of alpha-KG or increased accumulation of 2-HG (i.e. metabolic biomarker of mutant IDH1/2 enzyme activity) is considered to be a possible basis for the oncogenic properties of IDH mutants.
dcterms:title
Quantitative detection of an IDH2 mutation for minimal residual disease monitoring in acute myeloid leukemia patients and its comparison with mutations in the NPM1 gene Quantitative detection of an IDH2 mutation for minimal residual disease monitoring in acute myeloid leukemia patients and its comparison with mutations in the NPM1 gene
skos:prefLabel
Quantitative detection of an IDH2 mutation for minimal residual disease monitoring in acute myeloid leukemia patients and its comparison with mutations in the NPM1 gene Quantitative detection of an IDH2 mutation for minimal residual disease monitoring in acute myeloid leukemia patients and its comparison with mutations in the NPM1 gene
skos:notation
RIV/00216224:14110/13:00067476!RIV14-MSM-14110___
n5:predkladatel
n6:orjk%3A14110
n3:aktivita
n10:I
n3:aktivity
I
n3:cisloPeriodika
4
n3:dodaniDat
n12:2014
n3:domaciTvurceVysledku
n4:1344552 n4:3715434 n4:5755476 n4:4376285 n4:5378605 n4:4585623
n3:druhVysledku
n11:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
101206
n3:idVysledku
RIV/00216224:14110/13:00067476
n3:jazykVysledku
n18:eng
n3:klicovaSlova
PROGNOSIS; FREQUENT
n3:klicoveSlovo
n9:PROGNOSIS n9:FREQUENT
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[4C6EC45B7FEA]
n3:nazevZdroje
Leukemia & Lymphoma
n3:obor
n13:FD
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n12:2013
n3:svazekPeriodika
54
n3:tvurceVysledku
Ráčil, Zdeněk Tošková, Martina Timilsina, Shira Dvořáková, Dana Mayer, Jiří Rázga, Filip Ježíšková, Ivana
n3:wos
000315898100032
s:issn
1042-8194
s:numberOfPages
4
n19:doi
10.3109/10428194.2012.727414
n17:organizacniJednotka
14110