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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F13%3A00066458%21RIV14-MSM-14110___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Recent evidence suggests that energy metabolism contributes to molecular mechanisms controlling stem cell identity. For example, human embryonic stem cells (hESCs) receive their metabolic energy mostly via glycolysis rather than mitochondrial oxidative phosphorylation. This suggests a connection of metabolic homeostasis to stemness. Nicotinamide adenine dinucleotide (NAD) is an important cellular redox carrier and a cofactor for various metabolic pathways, including glycolysis. Therefore, accurate determination of NAD cellular levels and dynamics is of growing importance for understanding the physiology of stem cells. Conventional analytic methods for the determination of metabolite levels rely on linear calibration curves. However, in actual practice many two-enzyme cycling assays, such as the assay systems used in this work, display prominently nonlinear behavior. Recent evidence suggests that energy metabolism contributes to molecular mechanisms controlling stem cell identity. For example, human embryonic stem cells (hESCs) receive their metabolic energy mostly via glycolysis rather than mitochondrial oxidative phosphorylation. This suggests a connection of metabolic homeostasis to stemness. Nicotinamide adenine dinucleotide (NAD) is an important cellular redox carrier and a cofactor for various metabolic pathways, including glycolysis. Therefore, accurate determination of NAD cellular levels and dynamics is of growing importance for understanding the physiology of stem cells. Conventional analytic methods for the determination of metabolite levels rely on linear calibration curves. However, in actual practice many two-enzyme cycling assays, such as the assay systems used in this work, display prominently nonlinear behavior.
dcterms:title
Nonlinear Regression Models for Determination of Nicotinamide Adenine Dinucleotide Content in Human Embryonic Stem Cells Nonlinear Regression Models for Determination of Nicotinamide Adenine Dinucleotide Content in Human Embryonic Stem Cells
skos:prefLabel
Nonlinear Regression Models for Determination of Nicotinamide Adenine Dinucleotide Content in Human Embryonic Stem Cells Nonlinear Regression Models for Determination of Nicotinamide Adenine Dinucleotide Content in Human Embryonic Stem Cells
skos:notation
RIV/00216224:14110/13:00066458!RIV14-MSM-14110___
n7:predkladatel
n8:orjk%3A14110
n4:aktivita
n18:Z n18:P
n4:aktivity
P(ED1.100/02/0123), P(GAP206/11/0009), Z(MSM0021622430)
n4:cisloPeriodika
6
n4:dodaniDat
n20:2014
n4:domaciTvurceVysledku
n12:5235979 n12:4022181 n12:6879632 n12:6908799 n12:9569707
n4:druhVysledku
n19:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
91975
n4:idVysledku
RIV/00216224:14110/13:00066458
n4:jazykVysledku
n13:eng
n4:klicovaSlova
Biochemical assay; Enzymatic cycling; hESC-derived fibroblasts; Human embryonic stem cells; NAD; Nonlinear regression
n4:klicoveSlovo
n5:Biochemical%20assay n5:Nonlinear%20regression n5:Enzymatic%20cycling n5:Human%20embryonic%20stem%20cells n5:hESC-derived%20fibroblasts n5:NAD
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[BF6BC0BFE4B9]
n4:nazevZdroje
Stem Cell Reviews and Reports
n4:obor
n11:EB
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
7
n4:projekt
n9:GAP206%2F11%2F0009 n9:ED1.100%2F02%2F0123
n4:rokUplatneniVysledku
n20:2013
n4:svazekPeriodika
9
n4:tvurceVysledku
Kyrylenko, Sergiy Salykin, Anton Kyrylenko, Olga Glatz, Zdeněk Dvořák, Petr Musilová, Jindra Kuzmic, Petr
n4:wos
000327386500005
n4:zamer
n15:MSM0021622430
s:issn
1550-8943
s:numberOfPages
8
n21:doi
10.1007/s12015-013-9454-3
n14:organizacniJednotka
14110