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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F13%3A00065658%21RIV14-MZ0-14110___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Human papillomaviruses (HPV) are small circular, double-stranded DNA viruses infecting epithelial tissues. HPV types can be classified both as high-risk or low-risk. Of the more than 120 different identified types of HPV, the majority are involved in infections of the genital tract, cancer of the cervix, vulva, vagina and penis, and of non-anogenital localizations, such as the head and neck areas. From the point of view of the infection, human papillomaviruses have developed several molecular mechanisms to enable infected cells to suppress apoptosis. This review provides a comprehensive and critical summary of the current literature that focuses on cervical carcinoma and cancer of the head and neck caused by HPV. In particular, we discuss HPV virology, the molecular mechanisms of carcinogenesis, the role of the tumor suppressor protein p53 and the E6/E7 zinc finger proteins. Classification of HPV according to diagnosis is also described. Human papillomaviruses (HPV) are small circular, double-stranded DNA viruses infecting epithelial tissues. HPV types can be classified both as high-risk or low-risk. Of the more than 120 different identified types of HPV, the majority are involved in infections of the genital tract, cancer of the cervix, vulva, vagina and penis, and of non-anogenital localizations, such as the head and neck areas. From the point of view of the infection, human papillomaviruses have developed several molecular mechanisms to enable infected cells to suppress apoptosis. This review provides a comprehensive and critical summary of the current literature that focuses on cervical carcinoma and cancer of the head and neck caused by HPV. In particular, we discuss HPV virology, the molecular mechanisms of carcinogenesis, the role of the tumor suppressor protein p53 and the E6/E7 zinc finger proteins. Classification of HPV according to diagnosis is also described.
dcterms:title
Relevance of infection with human papillomavirus: The role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins (Review) Relevance of infection with human papillomavirus: The role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins (Review)
skos:prefLabel
Relevance of infection with human papillomavirus: The role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins (Review) Relevance of infection with human papillomavirus: The role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins (Review)
skos:notation
RIV/00216224:14110/13:00065658!RIV14-MZ0-14110___
n11:predkladatel
n12:orjk%3A14110
n4:aktivita
n18:P
n4:aktivity
P(ED1.1.00/02.0068), P(NT14337)
n4:cisloPeriodika
6
n4:dodaniDat
n14:2014
n4:domaciTvurceVysledku
n13:3931315 n13:1749072
n4:druhVysledku
n20:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
102250
n4:idVysledku
RIV/00216224:14110/13:00065658
n4:jazykVysledku
n19:eng
n4:klicovaSlova
human papillomavirus; head and neck cancer; metallothionein; protein p53; zinc finger proteins
n4:klicoveSlovo
n6:head%20and%20neck%20cancer n6:zinc%20finger%20proteins n6:protein%20p53 n6:human%20papillomavirus n6:metallothionein
n4:kodStatuVydavatele
GR - Řecká republika
n4:kontrolniKodProRIV
[09B320D2C572]
n4:nazevZdroje
International Journal of Oncology
n4:obor
n8:ED
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
8
n4:projekt
n5:ED1.1.00%2F02.0068 n5:NT14337
n4:rokUplatneniVysledku
n14:2013
n4:svazekPeriodika
43
n4:tvurceVysledku
Nejdl, Lukas Chudobova, Dagmar Adam, Vojtěch Kizek, Rene Jimenez, Ana Maria Jimenez Ruttkay-Nedecky, Branislav Gumulec, Jaromír Masařík, Michal
n4:wos
000330225800003
s:issn
1019-6439
s:numberOfPages
9
n16:doi
10.3892/ijo.2013.2105
n9:organizacniJednotka
14110