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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F13%3A00065642%21RIV14-MZ0-14110___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Multiple myeloma (MM) is a haematological malignancy characterized by the accumulation of clonal plasma cells (PCs) in the bone marrow (BM). Although novel therapeutic strategies have prolonged survival of patients, the disease remains difficult to treat with a high risk of relapse. The failure of therapy is thought to be associated with a persistent population of the so-called MM stem cells or myeloma initiating cells (MIC) that exhibit tumour-initiating potential, self-renewal and resistance to chemotherapy. However, the population responsible for the origin and sustainability of tumour mass has not been clearly characterized so far. This review summarizes current myeloma stem cell concepts and suggests that high phenotypic and intra-clonal heterogeneity, together with plasticity potential of MM might be other contributing factors explaining discrepancies among particular concepts and contributing to the treatment failure. Multiple myeloma (MM) is a haematological malignancy characterized by the accumulation of clonal plasma cells (PCs) in the bone marrow (BM). Although novel therapeutic strategies have prolonged survival of patients, the disease remains difficult to treat with a high risk of relapse. The failure of therapy is thought to be associated with a persistent population of the so-called MM stem cells or myeloma initiating cells (MIC) that exhibit tumour-initiating potential, self-renewal and resistance to chemotherapy. However, the population responsible for the origin and sustainability of tumour mass has not been clearly characterized so far. This review summarizes current myeloma stem cell concepts and suggests that high phenotypic and intra-clonal heterogeneity, together with plasticity potential of MM might be other contributing factors explaining discrepancies among particular concepts and contributing to the treatment failure.
dcterms:title
Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma
skos:prefLabel
Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma
skos:notation
RIV/00216224:14110/13:00065642!RIV14-MZ0-14110___
n15:predkladatel
n16:orjk%3A14110
n5:aktivita
n14:I n14:P
n5:aktivity
I, P(GAP304/10/1395), P(NT11154), P(NT13190)
n5:cisloPeriodika
5
n5:dodaniDat
n20:2014
n5:domaciTvurceVysledku
n10:1320440 n10:9622748 n10:1294172
n5:druhVysledku
n17:J
n5:duvernostUdaju
n18:S
n5:entitaPredkladatele
n19:predkladatel
n5:idSjednocenehoVysledku
90303
n5:idVysledku
RIV/00216224:14110/13:00065642
n5:jazykVysledku
n8:eng
n5:klicovaSlova
Malignant plasma cells; Multiple myeloma; Myeloma stem cells; Plasticity; Precursor B cells
n5:klicoveSlovo
n7:Myeloma%20stem%20cells n7:Multiple%20myeloma n7:Malignant%20plasma%20cells n7:Plasticity n7:Precursor%20B%20cells
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[D6B803F9FDC7]
n5:nazevZdroje
BRITISH JOURNAL OF HAEMATOLOGY
n5:obor
n6:FD
n5:pocetDomacichTvurcuVysledku
3
n5:pocetTvurcuVysledku
3
n5:projekt
n11:NT11154 n11:GAP304%2F10%2F1395 n11:NT13190
n5:rokUplatneniVysledku
n20:2013
n5:svazekPeriodika
163
n5:tvurceVysledku
Hájek, Roman Šváchová, Hana Okubote, Samuel Adeyinka
n5:wos
000326807400003
s:issn
0007-1048
s:numberOfPages
14
n13:doi
10.1111/bjh.12563
n4:organizacniJednotka
14110