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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F13%3A00065610%21RIV14-MZ0-14110___
rdf:type
skos:Concept n8:Vysledek
dcterms:description
In multiple myeloma (MM), biologic complexity originates from complex oncogenic processes involving somatic acquisition of myriad mutations coupled with genetic variability within the host. This pathogenically determined molecular heterogeneity predetermines clinical intricacy. In this study, we performed gene expression profi ling (GEP) focusing on centrosome-related genes to determine the molecular heterogeneity for centrosomeassociated genes in patients with MM. We identifi ed the gene pattern with an impact on myeloma pathogenesis. According to expression tendency, three subgroups of patients were established. The revealed molecular signature is related to overall survival as well as to clinical parameters and the International Staging System. Associations with integral clinical parameters allow us to proclaim the impact of the revealed functional gene set in MM genesis. In multiple myeloma (MM), biologic complexity originates from complex oncogenic processes involving somatic acquisition of myriad mutations coupled with genetic variability within the host. This pathogenically determined molecular heterogeneity predetermines clinical intricacy. In this study, we performed gene expression profi ling (GEP) focusing on centrosome-related genes to determine the molecular heterogeneity for centrosomeassociated genes in patients with MM. We identifi ed the gene pattern with an impact on myeloma pathogenesis. According to expression tendency, three subgroups of patients were established. The revealed molecular signature is related to overall survival as well as to clinical parameters and the International Staging System. Associations with integral clinical parameters allow us to proclaim the impact of the revealed functional gene set in MM genesis.
dcterms:title
Molecular heterogeneity and centrosome-associated genes in multiple myeloma Molecular heterogeneity and centrosome-associated genes in multiple myeloma
skos:prefLabel
Molecular heterogeneity and centrosome-associated genes in multiple myeloma Molecular heterogeneity and centrosome-associated genes in multiple myeloma
skos:notation
RIV/00216224:14110/13:00065610!RIV14-MZ0-14110___
n8:predkladatel
n9:orjk%3A14110
n3:aktivita
n17:P
n3:aktivity
P(GAP304/10/1395), P(NS10207), P(NT11154), P(NT13190)
n3:cisloPeriodika
9
n3:dodaniDat
n14:2014
n3:domaciTvurceVysledku
n10:8894272 n10:5132606 n10:3365891 n10:1753142 n10:6012329 Dementyeva, Elena n10:6933300 n10:9478426 n10:9622748
n3:druhVysledku
n18:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
89312
n3:idVysledku
RIV/00216224:14110/13:00065610
n3:jazykVysledku
n12:eng
n3:klicovaSlova
Multiple myeloma; centrosome abnormalities; gene expression profile
n3:klicoveSlovo
n6:centrosome%20abnormalities n6:gene%20expression%20profile n6:Multiple%20myeloma
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[D34D8773EFBB]
n3:nazevZdroje
Leukemia & Lymphoma
n3:obor
n16:FD
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
10
n3:projekt
n5:NS10207 n5:NT11154 n5:NT13190 n5:GAP304%2F10%2F1395
n3:rokUplatneniVysledku
n14:2013
n3:svazekPeriodika
54
n3:tvurceVysledku
Hájek, Roman Kryukov, Fedor Jarkovský, Jiří Kuglík, Petr Ševčíková, Sabina Budinská, Eva Ihnatová, Ivana Němec, Pavel Dementyeva, Elena Kubiczková, Lenka
n3:wos
000323492400022
s:issn
1042-8194
s:numberOfPages
7
n13:doi
10.3109/10428194.2013.764416
n15:organizacniJednotka
14110