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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F13%3A00065607%21RIV14-MZ0-14110___
rdf:type
skos:Concept n10:Vysledek
dcterms:description
Background: Multiple myeloma (MM) is a low proliferative tumor of postgerminal center plasma cell (PC). Centrosome amplification (CA) is supposed to be one of the mechanisms leading to chromosomal instability. Also, CA is associated with deregulation of cell cycle, mitosis, DNA repair and proliferation. The aim of our study was to evaluate the prognostic significance and possible role of CA in pathogenesis and analysis of mitotic genes as mitotic disruption markers. Design and methods: A total of 173 patients were evaluated for this study. CD138+ cells were separated by MACS. Immunofluorescent labeling of centrin was used for evaluation of centrosome amplification in PCs. Interphase FISH with cytoplasmic immunoglobulin light chain staining (cIg FISH) and qRT-PCR were performed on PCs. Results: Based on the immunofluorescent staining results, all patients were divided into two groups: CA positive (38.2%) and CA negative (61.8%). Background: Multiple myeloma (MM) is a low proliferative tumor of postgerminal center plasma cell (PC). Centrosome amplification (CA) is supposed to be one of the mechanisms leading to chromosomal instability. Also, CA is associated with deregulation of cell cycle, mitosis, DNA repair and proliferation. The aim of our study was to evaluate the prognostic significance and possible role of CA in pathogenesis and analysis of mitotic genes as mitotic disruption markers. Design and methods: A total of 173 patients were evaluated for this study. CD138+ cells were separated by MACS. Immunofluorescent labeling of centrin was used for evaluation of centrosome amplification in PCs. Interphase FISH with cytoplasmic immunoglobulin light chain staining (cIg FISH) and qRT-PCR were performed on PCs. Results: Based on the immunofluorescent staining results, all patients were divided into two groups: CA positive (38.2%) and CA negative (61.8%).
dcterms:title
Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma
skos:prefLabel
Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma
skos:notation
RIV/00216224:14110/13:00065607!RIV14-MZ0-14110___
n10:predkladatel
n11:orjk%3A14110
n3:aktivita
n16:P
n3:aktivity
P(GAP304/10/1395), P(NS10207), P(NT11154), P(NT13190)
n3:cisloPeriodika
77
n3:dodaniDat
n8:2014
n3:domaciTvurceVysledku
n6:5132606 n6:9622748 n6:6933300 n6:8894272 n6:1753142 n6:3365891 n6:9478426 n6:6012329
n3:druhVysledku
n17:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
65696
n3:idVysledku
RIV/00216224:14110/13:00065607
n3:jazykVysledku
n20:eng
n3:klicovaSlova
Multiple myeloma; Centrosome amplification; Overall survival
n3:klicoveSlovo
n14:Overall%20survival n14:Multiple%20myeloma n14:Centrosome%20amplification
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[0108BB49CCCC]
n3:nazevZdroje
Journal of Translational Medicine
n3:obor
n18:ED
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
11
n3:projekt
n13:NS10207 n13:NT11154 n13:GAP304%2F10%2F1395 n13:NT13190
n3:rokUplatneniVysledku
n8:2013
n3:svazekPeriodika
11
n3:tvurceVysledku
Ševčíková, Sabina Kubiczková, Lenka Dementyeva, Elena Kuglík, Petr Kryukov, Fedor Stefanikova, Zdena Ihnatová, Ivana Hájek, Roman Jarkovský, Jiří Minarik, Jiří Němec, Pavel
n3:wos
000317292200001
s:issn
1479-5876
s:numberOfPages
9
n19:doi
10.1186/1479-5876-11-77
n4:organizacniJednotka
14110