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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F13%3A00065582%21RIV14-MZ0-14110___
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Multiple myeloma (MM) is a malignancy of plasma cells (PCs) which accumulate in the bone marrow (BM), thus, leading to anemia, bone lesions, hypercalcemia, renal impairment and immune dysfunction. T regulatory (Treg) cells maintain immune homeostasis in healthy individuals by patrolling unwanted immune responses. Whereas in cancer patients, these cells are uncontrollably expanded, thereby, inhibiting the host anti-tumor responses. Majorly this work is focused to understand the role of Treg cells, including CD4 Treg cells and CD8 Treg cells in rendering the immune impairments in MM patients. This study clearly showed that both CD4 and CD8 Treg cells were functionally suppressive and increased in MM patients. These findings were confirmed by using different methods, including flow cytometry, functional and molecular studies (RT-PCR and western blot). Multiple myeloma (MM) is a malignancy of plasma cells (PCs) which accumulate in the bone marrow (BM), thus, leading to anemia, bone lesions, hypercalcemia, renal impairment and immune dysfunction. T regulatory (Treg) cells maintain immune homeostasis in healthy individuals by patrolling unwanted immune responses. Whereas in cancer patients, these cells are uncontrollably expanded, thereby, inhibiting the host anti-tumor responses. Majorly this work is focused to understand the role of Treg cells, including CD4 Treg cells and CD8 Treg cells in rendering the immune impairments in MM patients. This study clearly showed that both CD4 and CD8 Treg cells were functionally suppressive and increased in MM patients. These findings were confirmed by using different methods, including flow cytometry, functional and molecular studies (RT-PCR and western blot).
dcterms:title
Biology of Immune Regulation in Multiple Myeloma : Evaluation of immune regulatory cells and their clinical significance in patients with multiple myeloma Biology of Immune Regulation in Multiple Myeloma : Evaluation of immune regulatory cells and their clinical significance in patients with multiple myeloma
skos:prefLabel
Biology of Immune Regulation in Multiple Myeloma : Evaluation of immune regulatory cells and their clinical significance in patients with multiple myeloma Biology of Immune Regulation in Multiple Myeloma : Evaluation of immune regulatory cells and their clinical significance in patients with multiple myeloma
skos:notation
RIV/00216224:14110/13:00065582!RIV14-MZ0-14110___
n9:predkladatel
n18:orjk%3A14110
n3:aktivita
n5:P
n3:aktivity
P(GAP304/10/1395), P(NT11154), P(NT13190)
n3:dodaniDat
n12:2014
n3:domaciTvurceVysledku
n14:3042642 n14:9622748
n3:druhVysledku
n20:B
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
63487
n3:idVysledku
RIV/00216224:14110/13:00065582
n3:jazykVysledku
n16:eng
n3:klicovaSlova
PROGNOSIS; Dexamethasone; T regulatory cells; Thalidomide; Immune Suppression; Multiple Myeloma; FOXP3; Cyclophosphamide; Lénalidomide; monoclonal protein
n3:klicoveSlovo
n4:T%20regulatory%20cells n4:Thalidomide n4:Dexamethasone n4:L%C3%A9nalidomide n4:Multiple%20Myeloma n4:PROGNOSIS n4:monoclonal%20protein n4:FOXP3 n4:Cyclophosphamide n4:Immune%20Suppression
n3:kontrolniKodProRIV
[EDC23B3C8526]
n3:mistoVydani
Saarbrücken
n3:nazevEdiceCisloSvazku
Neuveden
n3:nazevZdroje
Biology of Immune Regulation in Multiple Myeloma : Evaluation of immune regulatory cells and their clinical significance in patients with multiple myeloma
n3:obor
n17:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetStranKnihy
160
n3:pocetTvurcuVysledku
2
n3:projekt
n11:GAP304%2F10%2F1395 n11:NT11154 n11:NT13190
n3:rokUplatneniVysledku
n12:2013
n3:tvurceVysledku
Hájek, Roman Muthu Raja, Karthick Raja
s:numberOfPages
160
n7:hasPublisher
LAP Lambert Academic Publishing
n15:isbn
9783659369148
n13:organizacniJednotka
14110