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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F12%3A00064926%21RIV13-MZ0-14110___
rdf:type
n4:Vysledek skos:Concept
dcterms:description
Evidence has recently indicated that the MRAS and HNF1A genetic polymorphisms are associated with coronary artery disease. The MRAS and HNF1A genes are located on chromosomes 3q and 12q within the regions where associations with diabetes and diabetic nephropathy occur. We thus performed genetic and functional analyses of these two genes to evaluate their impacts on diabetes and diabetic nephropathy. MRAS and HNF1A genetic polymorphisms were genotyped in 1399 Czech subjects including non-diabetic controls (339), type 1 (243) and type 2 (817) diabetic patients with and without diabetic nephropathy using TaqMan allelic discrimination. Gene expression levels in the kidneys of diabetic Goto-Kakizaki and Wistar rats were detected with real-time RT-PCR. Despite no significance in genetic analysis of diabetic subjects, SNP rs2259816 in the HNF1A gene tended to associate with diabetic nephropathy in type 1 diabetic patients. Evidence has recently indicated that the MRAS and HNF1A genetic polymorphisms are associated with coronary artery disease. The MRAS and HNF1A genes are located on chromosomes 3q and 12q within the regions where associations with diabetes and diabetic nephropathy occur. We thus performed genetic and functional analyses of these two genes to evaluate their impacts on diabetes and diabetic nephropathy. MRAS and HNF1A genetic polymorphisms were genotyped in 1399 Czech subjects including non-diabetic controls (339), type 1 (243) and type 2 (817) diabetic patients with and without diabetic nephropathy using TaqMan allelic discrimination. Gene expression levels in the kidneys of diabetic Goto-Kakizaki and Wistar rats were detected with real-time RT-PCR. Despite no significance in genetic analysis of diabetic subjects, SNP rs2259816 in the HNF1A gene tended to associate with diabetic nephropathy in type 1 diabetic patients.
dcterms:title
Genetic and Functional Analyses of MRAS and HNF1A Genes in Diabetes and Diabetic Nephropathy Genetic and Functional Analyses of MRAS and HNF1A Genes in Diabetes and Diabetic Nephropathy
skos:prefLabel
Genetic and Functional Analyses of MRAS and HNF1A Genes in Diabetes and Diabetic Nephropathy Genetic and Functional Analyses of MRAS and HNF1A Genes in Diabetes and Diabetic Nephropathy
skos:notation
RIV/00216224:14110/12:00064926!RIV13-MZ0-14110___
n4:predkladatel
n9:orjk%3A14110
n5:aktivita
n11:Z n11:I n11:P
n5:aktivity
I, P(NT11405), Z(MSM0021620807)
n5:cisloPeriodika
3
n5:dodaniDat
n7:2013
n5:domaciTvurceVysledku
n15:7988788
n5:druhVysledku
n16:J
n5:duvernostUdaju
n8:S
n5:entitaPredkladatele
n13:predkladatel
n5:idSjednocenehoVysledku
137890
n5:idVysledku
RIV/00216224:14110/12:00064926
n5:jazykVysledku
n17:eng
n5:klicovaSlova
MRAS; HNF1A; diabetic nephropathy; type 1 and 2 diabetes
n5:klicoveSlovo
n6:HNF1A n6:type%201%20and%202%20diabetes n6:MRAS n6:diabetic%20nephropathy
n5:kodStatuVydavatele
CZ - Česká republika
n5:kontrolniKodProRIV
[2F6984A079B9]
n5:nazevZdroje
Folia biologica
n5:obor
n20:FB
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
5
n5:projekt
n18:NT11405
n5:rokUplatneniVysledku
n7:2012
n5:svazekPeriodika
58
n5:tvurceVysledku
Brismar, K. Prazny, Michal Gu, H. F. Kaňková, Kateřina Horova, Eva
n5:wos
000306098400005
n5:zamer
n12:MSM0021620807
s:issn
0015-5500
s:numberOfPages
7
n19:organizacniJednotka
14110