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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F12%3A00061849%21RIV13-MZ0-14110___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
Dendritic cell (DC) immunotherapy is capable of generating tumour-specific immune responses. Different maturation strategies were previously tested to obtain DC capable of anti-cancer responses in vitro, usually with limited clinical benefit. Mutual comparison of currently used maturation strategies and subsequent complex evaluation of DC functions and their stimulatory capacity on T cells was performed in this study to optimize the DC vaccination strategy for further clinical application. DC were generated from monocytes using granulocyte–macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4, pulsed with whole tumour cell lysate and then matured with one of five selected maturation strategies or cultured without additional maturation stimulus. DC were characterized with regard to their surface marker expression, cytokine profiles, migratory capacity, allogeneic and autologous T cell stimulatory capacity as well as their specific cytotoxicity against tumour antigens. Dendritic cell (DC) immunotherapy is capable of generating tumour-specific immune responses. Different maturation strategies were previously tested to obtain DC capable of anti-cancer responses in vitro, usually with limited clinical benefit. Mutual comparison of currently used maturation strategies and subsequent complex evaluation of DC functions and their stimulatory capacity on T cells was performed in this study to optimize the DC vaccination strategy for further clinical application. DC were generated from monocytes using granulocyte–macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4, pulsed with whole tumour cell lysate and then matured with one of five selected maturation strategies or cultured without additional maturation stimulus. DC were characterized with regard to their surface marker expression, cytokine profiles, migratory capacity, allogeneic and autologous T cell stimulatory capacity as well as their specific cytotoxicity against tumour antigens.
dcterms:title
Complex evaluation of human monocyte-derived dendritic cells for cancer immunotherapy Complex evaluation of human monocyte-derived dendritic cells for cancer immunotherapy
skos:prefLabel
Complex evaluation of human monocyte-derived dendritic cells for cancer immunotherapy Complex evaluation of human monocyte-derived dendritic cells for cancer immunotherapy
skos:notation
RIV/00216224:14110/12:00061849!RIV13-MZ0-14110___
n19:predkladatel
n20:orjk%3A14110
n4:aktivita
n16:P
n4:aktivity
P(2B06058), P(NT11137)
n4:cisloPeriodika
11
n4:dodaniDat
n10:2013
n4:domaciTvurceVysledku
n9:7892489 n9:1642537 n9:4290135 n9:6522319
n4:druhVysledku
n18:J
n4:duvernostUdaju
n7:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
128174
n4:idVysledku
RIV/00216224:14110/12:00061849
n4:jazykVysledku
n13:eng
n4:klicovaSlova
cancer immunotherapy; cytotoxicity; dendritic cell; interleukin-12; maturation; migration
n4:klicoveSlovo
n5:cytotoxicity n5:dendritic%20cell n5:migration n5:maturation n5:interleukin-12 n5:cancer%20immunotherapy
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[15A211C952C0]
n4:nazevZdroje
Journal of Cellular and Molecular Medicine
n4:obor
n14:FD
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
4
n4:projekt
n17:2B06058 n17:NT11137
n4:rokUplatneniVysledku
n10:2012
n4:svazekPeriodika
16
n4:tvurceVysledku
Michálek, Jaroslav Vopěnková, Kateřina Burešová, Ivana Mollová, Klára
n4:wos
000310555200026
s:issn
1582-1838
s:numberOfPages
11
n15:doi
10.1111/j.1582-4934.2012.01614.x
n11:organizacniJednotka
14110