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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F11%3A00055888%21RIV12-MSM-14110___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Cognitive impairment exists in Parkinsons disease (PD) as a transitional state between cognitively intact and demented PD patients. It seems to be a risk factor for the development of dementia in PD, but the precise criteria and unfavorable cognitive profile of mild cognitive impairment in PD (MCI-PD) have not yet been established. The concept may turn to be different from that in Alzheimers disease since we search for those already diagnosed PD patients who are at risk of developing dementia. In addition, clinical variables specific for PD also play role. Importantly, MCI possesses a metabolic basis in PD. Various biomarkers particularly including neuropsychological testing and the brain imaging hold promise in identification of MCI-PD patients with unfavorable prognoses. Well-designed longitudinal studies in MCI-PD cohorts are needed to assess the sensitivity and specificity of the PD-MCI designation as far as dementia development is concerned. Cognitive impairment exists in Parkinsons disease (PD) as a transitional state between cognitively intact and demented PD patients. It seems to be a risk factor for the development of dementia in PD, but the precise criteria and unfavorable cognitive profile of mild cognitive impairment in PD (MCI-PD) have not yet been established. The concept may turn to be different from that in Alzheimers disease since we search for those already diagnosed PD patients who are at risk of developing dementia. In addition, clinical variables specific for PD also play role. Importantly, MCI possesses a metabolic basis in PD. Various biomarkers particularly including neuropsychological testing and the brain imaging hold promise in identification of MCI-PD patients with unfavorable prognoses. Well-designed longitudinal studies in MCI-PD cohorts are needed to assess the sensitivity and specificity of the PD-MCI designation as far as dementia development is concerned.
dcterms:title
Mild cognitive impairment exists in Parkinson's disease Mild cognitive impairment exists in Parkinson's disease
skos:prefLabel
Mild cognitive impairment exists in Parkinson's disease Mild cognitive impairment exists in Parkinson's disease
skos:notation
RIV/00216224:14110/11:00055888!RIV12-MSM-14110___
n12:predkladatel
n20:orjk%3A14110
n3:aktivita
n16:Z
n3:aktivity
Z(MSM0021622404)
n3:cisloPeriodika
8
n3:dodaniDat
n6:2012
n3:domaciTvurceVysledku
n18:6033040
n3:druhVysledku
n14:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
212539
n3:idVysledku
RIV/00216224:14110/11:00055888
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Brain imaging; Executive; Memory; Mild cognitive impairment; Parkinsons disease
n3:klicoveSlovo
n8:Executive n8:Parkinsons%20disease n8:Mild%20cognitive%20impairment n8:Memory n8:Brain%20imaging
n3:kodStatuVydavatele
AT - Rakouská republika
n3:kontrolniKodProRIV
[AFC58DD400A1]
n3:nazevZdroje
Journal of Neural Transmission
n3:obor
n9:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:rokUplatneniVysledku
n6:2011
n3:svazekPeriodika
118
n3:tvurceVysledku
Rektorová, Irena
n3:wos
000293244800008
n3:zamer
n7:MSM0021622404
s:issn
0300-9564
s:numberOfPages
5
n17:doi
10.1007/s00702-011-0674-x
n5:organizacniJednotka
14110