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Statements

Subject Item
n2:RIV%2F00216224%3A14110%2F11%3A00050101%21RIV12-GA0-14110___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Nestin is considered to be a characteristic marker of multipotent proliferative precursors found in some embryonic and fetal tissues. Its expression might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells in solid tumors. Unexpectedly, nestin protein was detected in mature CD138+CD38+ plasma cells of multiple myeloma patients and statistical analysis confirmed significant differences between myeloma patients and control group without hematological malignancy. Our results represent the first evidence of nestin expression in multiple myeloma. Further studies are required to elucidate the role of this protein in multiple myeloma. Nestin is considered to be a characteristic marker of multipotent proliferative precursors found in some embryonic and fetal tissues. Its expression might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells in solid tumors. Unexpectedly, nestin protein was detected in mature CD138+CD38+ plasma cells of multiple myeloma patients and statistical analysis confirmed significant differences between myeloma patients and control group without hematological malignancy. Our results represent the first evidence of nestin expression in multiple myeloma. Further studies are required to elucidate the role of this protein in multiple myeloma.
dcterms:title
Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients
skos:prefLabel
Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients
skos:notation
RIV/00216224:14110/11:00050101!RIV12-GA0-14110___
n15:predkladatel
n16:orjk%3A14110
n3:aktivita
n18:P n18:Z
n3:aktivity
P(GAP304/10/1395), P(LC06027), Z(MSM0021622434)
n3:cisloPeriodika
8
n3:dodaniDat
n17:2012
n3:domaciTvurceVysledku
n4:1294172 n4:3042642 n4:6231616 n4:9622748 n4:1447963 n4:4954130
n3:druhVysledku
n19:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n21:predkladatel
n3:idSjednocenehoVysledku
232342
n3:idVysledku
RIV/00216224:14110/11:00050101
n3:jazykVysledku
n12:eng
n3:klicovaSlova
Nestin; Plasma cells; Multiple myeloma; Myeloma stem cells; Flow cytometry
n3:klicoveSlovo
n5:Myeloma%20stem%20cells n5:Multiple%20myeloma n5:Plasma%20cells n5:Nestin n5:Flow%20cytometry
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[EF51850E0CCA]
n3:nazevZdroje
Leukemia Research
n3:obor
n9:FD
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n7:GAP304%2F10%2F1395 n7:LC06027
n3:rokUplatneniVysledku
n17:2011
n3:svazekPeriodika
35
n3:tvurceVysledku
Muthu Raja, Karthick Raja Šána, Jiří Říhová, Lucie Hájek, Roman Pour, Luděk Šváchová, Hana
n3:wos
000292735300007
n3:zamer
n13:MSM0021622434
s:issn
0145-2126
s:numberOfPages
6
n14:doi
10.1016/j.leukres.2011.03.001
n10:organizacniJednotka
14110